| Sissala District | |
| Settlement Type: | Former District |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Sissala District within Upper West |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Name1: | Upper West |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Tumu |
| Leader Title: | District Executive |
| Population As Of: | 2013 |
| Population Total: | — |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 10.8728°N -1.9803°W |
| Iso Code: | GH-UW-SS |
Sissala District is a former district that was located in Upper West Region, Ghana. Originally created as an ordinary district assembly in 1988. However, in July 2004, it was split off into two new districts: Sissala East District (which it was elevated to municipal district assembly status on 15 March 2018; capital: Tumu) and Sissala West District (capital: Gwollu). The district assembly was located in the northeast part of Upper West Region and had Tumu as its capital town.