| Honorific-Prefix: | Mar |
| Shemon VI | |
| Church: | Church of the East |
| See: | Seleucia-Ctesiphon |
| Patriarch Of: | Patriarch of the Church of the East |
| Patriarch of All the East | |
| Residence: | Rabban Hormizd Monastery |
| Enthroned: | 1504 |
| Ended: | 5 August 1538 |
| Predecessor: | Eliya V |
| Successor: | Shemon VII Ishoyahb |
| Birth Date: | 15th century |
| Death Date: | 5 August 1538 |
| Buried: | Rabban Hormizd Monastery |
Mar Shemon VI (also written Shimun VI) was Patriarch of the Church of the East from 1504 until his death on 5 August 1538. Shemon is credited with revising the East Syriac Rite, replacing commemorations of traditional saints and martyrs with new ones, especially for those who had founded monasteries. Following his death, he was succeeded as Patriarch by his brother Shemon VII Ishoyahb, who had been natar kursya (designated successor) throughout his reign; since the reign of Shemon IV the role of Patriarch had been passed hereditarily. Shemon VI was buried alongside other Patriarchs of his era at Rabban Hormizd Monastery near Mosul, his residence while he had been Patriarch; his epitaph, recorded by Vosté, was inscribed by a priest named Israel.