| Sethu Superfast Express | |
| Type: | Superfast |
| Locale: | Tamil Nadu |
| Operator: | Southern Railway |
| Start: | (MS) |
| Stops: | 15 |
| End: | (RMM) |
| Distance: | 603km (375miles) |
| Journeytime: | 9 hrs 30 mins |
| Frequency: | Daily |
| Class: | AC First, AC 2 Tier, AC 3 Tier, Sleeper Class, General Unreserved |
| Seating: | Yes |
| Sleeping: | Yes |
| Catering: | E-Catering, On-board catering |
| Observation: | Large windows |
| Baggage: | No |
| Otherfacilities: | Below the seats |
| Stock: | ICF coach |
| Gauge: | Broad Gauge |
| Trainnumber: | 22661 / 22662 |
| Speed: | 62km/h average including halts. |
The 22661 / 22662 Sethu Superfast Express is a Superfast train route of the Southern Railway zone of the Indian Railways and runs between Chennai Egmore and Rameswaram via Chord line. It is a standard train consisting of 23 coaches. The train covers a distance of with an average speed of .
The King of Ramanathapuram Samasthanam (Princely State) in Tamil Nadu bore the title Sethupathy. So the train running through this princely territory is named as Sethu express
The other reason being it connects the peninsular sub continental India with the Island city of Rameshwaram using the Pamban bridge.
Total number of coaches: 23