| Sesto Campano | |
| Official Name: | Comune di Sesto Campano |
| Coordinates: | 41.4167°N 19°W |
| Region: | Molise |
| Province: | Isernia (IS) |
| Frazioni: | Roccapipirozzi |
| Mayor: | Luigi Paolone |
| Area Total Km2: | 36.6 |
| Population Footnotes: | [1] |
| Population Total: | 2387 |
| Population As Of: | 30 September 2016 |
| Population Demonym: | Sestolesi |
| Postal Code: | 86078 |
| Area Code: | 0865 |
Sesto Campano is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about 50km (30miles) southwest of Campobasso and about 25km (16miles) southwest of Isernia. The municipality is located in the south of its province, close to the borders of Molise with Campania and Lazio. It borders with the municipality Venafro and four others belonging to the Province of Caserta: Ciorlano, Mignano Monte Lungo, Pratella and Presenzano.