Sertoli cell nodule explained

A Sertoli cell nodule is a benign proliferation of Sertoli cells that arises in association with cryptorchidism (undescended testis).^[1] They are not composed of a clonal cell population, i.e. neoplastic; thus, technically, they should not be called an adenoma.^[2] __TOC__

Pathology

Sertoli cell nodules are unencapsulated nodules that consist of:^{[2] [3] [4]}

1. cells arranged in well-formed tubules (that vaguely resemble immature Sertoli cells), with
2. bland hyperchromatic oval/round nuclei that are stratified, and
3. may contain eosinophilic (hyaline) blob in lumen (centre).

Further reading

• Testis, Sex Cord Stromal Tumor - eMedicine.
• 10.1136/jcp.2004.015982 . 15280399 . 1770379 . Sertoli cell nodules in the undescended testis: A histochemical, immunohistochemical, and ultrastructural study of hyaline deposits . Journal of Clinical Pathology . 57 . 8 . 802–806 . 2004 . Govender . D. . Sing . Y. . Chetty . R. .
• 10.1136/jcp.2005.035253 . 17071812 . 1860496 . Giant Sertoli cell nodule of the testis: Distinction from other Sertoli cell lesions . Journal of Clinical Pathology . 59 . 11 . 1223–1225 . 2006 . Barghorn . A. . Alioth . H-R . Hailemariam . S. . Bannwart . F. . Ulbright . T. M. .

Notes and References

1. Web site: Sertoli cell nodule . 2023-11-04 . www.pathologyoutlines.com.
2. Book: Tadrous, Paul J. . Diagnostic criteria handbook in histopathology: a surgical pathology vade mecum . limited . 2007 . John Wiley & Sons Canada . 978-0-470-51903-5 . 227 =.
3. Web site: Ashwagandha . 19 November 2018. 2018-09-24 .
4. Ricco R, Bufo P . [Histologic study of 3 cases of so-called tubular adenoma of the testis] . Italian . Boll. Soc. Ital. Biol. Sper. . 56 . 20 . 2110–5 . October 1980 . 6109541 .