Sepetaprost Explained

Legal Status:Investigational
Cas Number:1262873-06-2
Pubchem:50902259
Iuphar Ligand:9875
Drugbank:DB12043
Chemspiderid:32698273
Unii:79O7855J4G
Chembl:4297633
Synonyms:STN-1012600
Iupac Name:propan-2-yl 4-[(3S,5aR,6R,7R,8aS)-6-[(E,3R)-4-(2,5-difluorophenoxy)-3-hydroxybut-1-enyl]-7-hydroxy-3,4,5,5a,6,7,8,8a-octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate
C:26
H:36
F:2
O:6
Smiles:CC(C)OC(=O)CCC[C@H]1CC[C@H]2[C@H](C[C@H]([C@@H]2/C=C/[C@H](COC3=C(C=CC(=C3)F)F)O)O)OC1
Stdinchi:1S/C26H36F2O6/c1-16(2)34-26(31)5-3-4-17-6-9-21-20(23(30)13-24(21)32-14-17)10-8-19(29)15-33-25-12-18(27)7-11-22(25)28/h7-8,10-12,16-17,19-21,23-24,29-30H,3-6,9,13-15H2,1-2H3/b10-8+/t17-,19+,20+,21+,23+,24-/m0/s1
Stdinchikey:BKVUSNOUTQMSBE-XCMGCKIWSA-N

Sepetaprost is an investigational new drug that is being evaluated for the treatment of open angle glaucoma and ocular hypertension.[1] It is an agonist of the prostaglandin EP3 and F receptors.[2]

Notes and References

  1. Web site: Sepetaprost - Santen Pharmaceutical . AdisInsight . Springer Nature Switzerland AG .
  2. Sharif NA, Odani-Kawabata N, Lu F, Pinchuk L . FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating ocular hypertension and glaucoma . Experimental Eye Research . 229 . 109415 . April 2023 . 36803996 . 10.1016/j.exer.2023.109415 .