| Official Name: | Sena Madureira |
| Pushpin Map: | Brazil |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Brazil |
| Subdivision Type: | Country |
| Subdivision Name: |  Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | North |
| Subdivision Type2: | State |
| Subdivision Name2: | Acre |
| Leader Title: | Mayor |
| Leader Name: | Mazinho Serafim (MDB) |
| Established Title: | Founded |
| Established Date: | September 25, 1904 (117 years) |
| Unit Pref: | Imperial |
| Area Total Km2: | 25278 |
| Population As Of: | 2020 est [1] |
| Population Total: | 46,511 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | ACT |
| Utc Offset: | -5 |
| Coordinates: | -9.0658°N -68.6569°W |
| Area Code: | +55 (68) |
Sena Madureira (pronounced as /pt/) is a municipality located in the center of the Brazilian state of Acre. Its population is 46,511 and its area is, making it the largest municipality in the state. It has a climate which combines temperatures of with humidities in the upper 90s percent, all year round. It is 143 km from Rio Branco.The oldest church in Acre state is located in Sena Madureira, the Nossa Senhora da Imaculada Conceição Church (1910).
The municipality contains part of the Rio Acre Ecological Station.It also contains part of the Chico Mendes Extractive Reserve, a sustainable use environmental unit created in 1990.It contains the Macauã National Forest, a sustainable use conservation unit created in 1988.It also contains the São Francisco National Forest, a sustainable use conservation unit created in 2001.It contains 98% of the Cazumbá-Iracema Extractive Reserve, established in 2002 to support sustainable use of the natural resources by the traditional population.The municipality contains about 12% of the Chandless State Park, created in 2004, which protects an area of rainforest with bamboos that contains various endemic species of flora and fauna.It contains about 27% of the Antimary State Forest, a sustainable use conservation unit established in 1997.