Semaphorin 3E Explained

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene.^[1]

Function

Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.

This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].

Further reading

• Lalani SR, Safiullah AM, Molinari LM, Fernbach SD, Martin DM, Belmont JW . SEMA3E mutation in a patient with CHARGE syndrome . J. Med. Genet. . 41 . 7 . e94 . July 2004 . 15235037 . 1735828 . 10.1136/jmg.2003.017640.
• Kigel B, Varshavsky A, Kessler O, Neufeld G . Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells . PLOS ONE . 3 . 9 . e3287 . September 2008 . 18818766 . 2538586 . 10.1371/journal.pone.0003287 . 2008PLoSO...3.3287K . free .
• Roodink I, Kats G, van Kempen L, Grunberg M, Maass C, Verrijp K, Raats J, Leenders W . Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression . Am. J. Pathol. . 173 . 6 . 1873–81 . December 2008 . 18974298 . 2626397 . 10.2353/ajpath.2008.080136 .
• Sokolowski M, Wasserman J, Wasserman D . Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters . Mol. Psychiatry . 15 . 1 . 10–1 . January 2010 . 20029409 . 10.1038/mp.2009.70 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz JM, Rizzolio S, Rolny C, Christensen C, Bertotti A, Sarotto I, Risio M, Trusolino L, Weitz J, Schneider M, Mazzone M, Mazzone M, Comoglio PM, Tamagnone L . Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice . J. Clin. Invest. . 120 . 8 . 2684–98 . August 2010 . 20664171 . 2912191 . 10.1172/JCI42118 . 2318/130565 .
• Blanc V, Nariculam J, Munson P, Freeman A, Klocker H, Masters J, Williamson M . A role for class 3 semaphorins in prostate cancer . Prostate . 71 . 6 . 649–58 . May 2011 . 20949546 . 10.1002/pros.21281 . 34734719 .
• Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A . Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice . J. Clin. Invest. . 121 . 5 . 1974–85 . May 2011 . 21505259 . 3083763 . 10.1172/JCI44900 .
• Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML . The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle . J. Biol. Chem. . 286 . 26 . 23521–32 . July 2011 . 21555518 . 3123115 . 10.1074/jbc.M111.220178 . free .

Notes and References

1. Web site: Entrez Gene: Semaphorin 3E. 2018-04-26.