Selective receptor modulator explained

In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.^[1] A SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.

Classes

Classes of selective receptor modulators include:

• Selective androgen receptor modulator (SARM)
• Selective estrogen receptor modulator (SERM)
• Selective glucocorticoid receptor modulator (SEGRM)
• Selective progesterone receptor modulator (SPRM)
• Selective PPAR modulator (SPPARM) including SPPARMγ (affecting the PPARγ) and SPPARMα (PPARα)

See also

• Agonist–antagonist
• Selective glucocorticoid receptor agonist (SEGRA)

Notes and References

1. Smith CL, O'Malley BW . Coregulator function: a key to understanding tissue specificity of selective receptor modulators . Endocr. Rev.. 25 . 1 . 45–71 . February 2004 . 14769827 . 10.1210/er.2003-0023. free .