Secretin receptor explained

The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the secretin receptor family, also called class B GPCR subfamily.^[1]

Interactions

The secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide.^[2]

References

Further reading

• Ulrich CD, Holtmann M, Miller LJ . Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors . Gastroenterology . 114 . 2 . 382–97 . February 1998 . 9453500 . 10.1016/S0016-5085(98)70491-3 .
• Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT . Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release . The American Journal of Physiology . 263 . 6 Pt 1 . G901-7 . December 1992 . 10.1152/ajpgi.1992.263.6.G901 . 1335692 .
• Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S . Molecular cloning and expression of a cDNA encoding the secretin receptor . The EMBO Journal . 10 . 7 . 1635–41 . July 1991 . 1646711 . 452832 . 10.1002/j.1460-2075.1991.tb07686.x.
• Robberecht P, De Neef P, Waelbroeck M, Camus JC, Scemama JL, Fourmy D, Pradayrol L, Vaysse N, Christophe J . Secretin receptors in human pancreatic membranes . Pancreas . 3 . 5 . 529–35 . 1988 . 3186683 . 10.1097/00006676-198810000-00004 . 23220534 .
• Chow BK . Molecular cloning and functional characterization of a human secretin receptor . Biochemical and Biophysical Research Communications . 212 . 1 . 204–11 . July 1995 . 7612008 . 10.1006/bbrc.1995.1957 .
• Patel DR, Kong Y, Sreedharan SP . Molecular cloning and expression of a human secretin receptor . Molecular Pharmacology . 47 . 3 . 467–73 . March 1995 . 7700244 .
• Holtmann MH, Hadac EM, Miller LJ . Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors . The Journal of Biological Chemistry . 270 . 24 . 14394–8 . June 1995 . 7782300 . 10.1074/jbc.270.24.14394 . free .
• Jiang S, Ulrich C . Molecular cloning and functional expression of a human pancreatic secretin receptor . Biochemical and Biophysical Research Communications . 207 . 3 . 883–90 . February 1995 . 7864894 . 10.1006/bbrc.1995.1268 .
• Sreedharan SP, Patel DR, Huang JX, Goetzl EJ . Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor . Biochemical and Biophysical Research Communications . 193 . 2 . 546–53 . June 1993 . 8390245 . 10.1006/bbrc.1993.1658 .
• Mark HF, Chow BK . Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry . Genomics . 29 . 3 . 817–8 . October 1995 . 8575789 . 10.1006/geno.1995.9922 .
• Vilardaga JP, di Paolo E, de Neef P, Waelbroeck M, Bollen A, Robberecht P . Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin . Biochemical and Biophysical Research Communications . 218 . 3 . 842–6 . January 1996 . 8579602 . 10.1006/bbrc.1996.0150 .
• Chow BK . Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor . Receptors & Signal Transduction . 7 . 3 . 143–50 . 1998 . 9440501 .
• Shetzline MA, Premont RT, Walker JK, Vigna SR, Caron MG . A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor . The Journal of Biological Chemistry . 273 . 12 . 6756–62 . March 1998 . 9506976 . 10.1074/jbc.273.12.6756 . free .
• Ho PK, Fong RS, Kai HS, Lau EH, Ngan ES, Cotton CU, Chow BK . The human secretin receptor gene: genomic organization and promoter characterization . FEBS Letters . 455 . 3 . 209–14 . July 1999 . 10437774 . 10.1016/S0014-5793(99)00864-9 . 1197008 .
• Pang RT, Ng SS, Cheng CH, Holtmann MH, Miller LJ, Chow BK . Role of N-linked glycosylation on the function and expression of the human secretin receptor . Endocrinology . 140 . 11 . 5102–11 . November 1999 . 10537138 . 10.1210/endo.140.11.7134 . free .
• Chan KY, Pang RT, Chow BK . Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor . Endocrinology . 142 . 9 . 3926–34 . September 2001 . 11517171 . 10.1210/endo.142.9.8389 . free .
• Pang RT, Lee LT, Ng SS, Yung WH, Chow BK . CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene . Molecular Endocrinology . 18 . 2 . 471–83 . February 2004 . 14645499 . 10.1210/me.2003-0245 . free .

External links

• IUPHAR GPCR Database - Secretin receptor

Notes and References

1. Dong M, Miller LJ . Molecular pharmacology of the secretin receptor . Receptors & Channels . 8 . 3–4 . 189–200 . 2002 . 12529936 . 10.1080/10606820213686 .
2. Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT . Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release . The American Journal of Physiology . 263 . 6 Pt 1 . G901-7 . December 1992 . 10.1152/ajpgi.1992.263.6.G901 . 1335692 .