| Santo Domingo, Antioquia | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Map: | Colombia |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Colombia |
| Coordinates: | 6.4708°N -75.1658°W |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | Antioquia Department |
| Subdivision Type2: | Subregion |
| Subdivision Name2: | Northeastern |
| Area Footnotes: | [1] |
| Area Total Km2: | 271 |
| Elevation M: | 1975 |
| Population Total: | 12394 |
| Population As Of: | 2018 |
| Population Density Km2: | auto |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
Santo Domingo is a town and municipality in the Colombian department of Antioquia. Part of the subregion of Northeastern Antioquia, it lies at an altitude of 1,975 m (6,480 ft) above sea level.
The municipio was founded in 1778 by Don Juan Gregorio Duque. In 1858, the writer Tomás Carrasquilla was born here.