| Official Name: | Santo Amaro |
| Mapsize: | 250px |
| Image Map1: | Estação Santo Amaro.jpg |
| Subdivision Type: | Country |
| Subdivision Name: | Brazil |
| Subdivision Type1: | State |
| Subdivision Name1: | São Paulo |
| Subdivision Type2: | City |
| Subdivision Name2: | São Paulo |
| Government Type: | Subprefecture |
| Leader Title: | Subprefect |
| Leader Name: | Ailton Araujo Brandão |
| Area Total Km2: | 15.6 |
| Population As Of: | 2000 |
| Population Total: | 52.411 |
| Population Density Km2: | 3.360 |
| Blank Name: | HDI |
| Blank Info: | 0.943 –high |
| Website: | Subprefecture of Santo Amaro |
Santo Amaro is a district in the subprefecture of the same name in the southern area of the city of São Paulo, Brazil. It was formerly a separate municipality until 1933, when it was incorporated to the municipality of São Paulo.
The district of Santo Amaro represents the plurality of Brazilian citizens, its best known part is Largo 13 de Maio where the Santo Amaro Cathedral is located and also the zero mark.[1]
A German school, Ginasio Humboldt Santo Amaro, was previously in Santo Amaro.[2]