| Settlement Type: | municipality |
| Official Name: | Santiago de Alcántara, Spain |
| Subdivision Name3: | Santiago de Alcántara |
| Area Total Km2: | 95 |
| Elevation M: | 342 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
Santiago de Alcántara is a municipality located in the province of Cáceres, Extremadura, Spain. According to the 2006 census (INE), the municipality has a population of 724 inhabitants.