| Santa María | |
| Settlement Type: | Municipality |
| Pushpin Map: | Nicaragua |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Nicaragua |
| Subdivision Type: | Country |
| Subdivision Name: |  Nicaragua |
| Subdivision Type1: | Department |
| Subdivision Name1: | Nueva Segovia Department |
| Unit Pref: | Imperial |
| Area Total Km2: | 158 |
| Population As Of: | 2005 |
| Population Total: | 4404 |
| Population Density Km2: | auto |
| Population Urban: | 549 |
| Coordinates: | 13.75°N -129°W |
Santa María is a municipality in the Nueva Segovia Department of Nicaragua.