| Settlement Type: | municipality |
| Official Name: | Santa Cruz de Paniagua, Spain |
| Subdivision Name3: | Santa Cruz de Paniagua |
| Area Total Km2: | 83 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
Santa Cruz de Paniagua is a municipality located in the province of Cáceres, Extremadura, Spain. According to the 2006 census (INE), the municipality has a population of 372 inhabitants.