| San Salvador Department | |
| Native Name: | Departamento San Salvador |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of San Salvador in Argentina |
| Coordinates: | -31.6167°N -98°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Entre Ríos |
| Seat Type: | Seat |
| Seat: | San Salvador |
| Unit Pref: | Metric |
| Area Total Km2: | 1228 |
| Population Total: | 17357 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
The San Salvador Department (in Spanish, Departamento San Salvador) is an administrative subdivision (departamento) of Entre Ríos Province, Argentina, created in 1995. It is located in the center-east of the province.
The department has 17,357 inhabitants as per the 2010 census [INDEC], which are distributed in 4 districts. The head town is San Salvador, which has a population of 13,228. Other towns are General Campos, Colonia Baylina, San Ernesto and Walter Moss.