| San Pancrazio Salentino | |
| Official Name: | Comune di San Pancrazio Salentino |
| Shield Alt: | coat of arms of San Pancrazio Salentino |
| Pushpin Label Position: | left |
| Coordinates: | 40.4167°N 67°W |
| Region: | Apulia |
| Province: | (BR) |
| Area Total Km2: | 55 |
| Population Footnotes: | [1] |
| Population Total: | 10289 |
| Population As Of: | 30 September 2012 |
| Population Demonym: | Sanpancraziesi or Sampancraziesi |
| Elevation M: | 62 |
| Saint: | St. Pancras of Rome |
| Day: | 12 May |
| Postal Code: | 72026 |
| Area Code: | 0831 |
San Pancrazio Salentino (Brindisino: Sicilian: Sammangràziu) is a comune in the province of Brindisi in Apulia, on the south-east Italy coast. Its main economic activities are tourism and the growing of olives and grapes.
San Pancrazio Salentino is twinned with:
Bisceglie, Italy