| San Isidro de Maino | |
| Native Name Lang: | es |
| Settlement Type: | District |
| Mapsize: | frameless |
| Subdivision Type: | Country |
| Subdivision Name: |  Peru |
| Subdivision Type1: | Region |
| Subdivision Name1: | Amazonas |
| Subdivision Type2: | Province |
| Subdivision Name2: | Chachapoyas |
| Parts Type: | Subdivisions |
| Parts Style: | para |
| Established Title: | Founded |
| Established Date: | March 25, 1952 |
| Seat Type: | Capital |
| Seat: | Maino |
| Leader Title: | Mayor |
| Leader Name: | Victor Augusto Alvarez (2019-2022) |
| Unit Pref: | Metric |
| Area Total Km2: | 101.67 |
| Elevation M: | 2325 |
| Population Total: | 580 |
| Population As Of: | 2017 |
| Population Density Km2: | auto |
| Timezone1: | PET |
| Utc Offset1: | -5 |
| Blank Name Sec1: | UBIGEO |
| Blank Info Sec1: | 010119 |
San Isidro de Maino is a district of the province of Chachapoyas in Peru. Its capital is the town of San Isidro de Mayno.
The district covers an area of 101.67 km² with an altitude ranging between 1,200 and 2,500 m above sea level in the district capital, and up to 2,800 m in the high part named "The Pajonal". The climate is dry and moderately cold.
In the north and west the district of San Isidro de Maino shares a border with the Levanto District, in the East with the Soloco District and the Cochamal District, and in the south with the Magdalena District.