| San Francisco del Yeso | |
| Native Name Lang: | es |
| Settlement Type: | District |
| Mapsize: | frameless |
| Subdivision Type: | Country |
| Subdivision Name: |  Peru |
| Subdivision Type1: | Region |
| Subdivision Name1: | Amazonas |
| Subdivision Type2: | Province |
| Subdivision Name2: | Luya |
| Parts Type: | Subdivisions |
| Parts Style: | para |
| Established Title: | Founded |
| Established Date: | August 16, 1920 |
| Seat Type: | Capital |
| Seat: | San Francisco del Yeso |
| Leader Title: | Mayor |
| Leader Name: | Daniel Vargas Vergaray |
| Unit Pref: | Metric |
| Area Total Km2: | 113.94 |
| Elevation M: | 2400 |
| Population Total: | 738 |
| Population As Of: | 2005 census |
| Population Density Km2: | auto |
| Timezone1: | PET |
| Utc Offset1: | -5 |
| Blank Name Sec1: | UBIGEO |
| Blank Info Sec1: | 010517 |
San Francisco del Yeso is a district of Luya Province, Peru. One of its best-known attractions are the ruins of Chachapoya. The region is famous for its plaster mines and crafts.
Its official holiday is on September 23, but religious festivities take place from September 23–27. Special foods consumed during these celebrations are the Locro and Cuy.
On the north, the district borders Santo Tomás Luya; on the East, it borders Castilla Chachapoyas and Montevideo Chachapoyas; on the south it borders Leymebamba Chachapoyas; and on the west, it borders Cocabamba.