| Samuel Gross | |
| State1: | Pennsylvania |
| District1: | 2nd |
| Term Start1: | March 4, 1819 |
| Term End1: | March 3, 1823 |
| Preceded1: | See below |
| Succeeded1: | Joseph Hemphill |
| Office2: | Member of the Pennsylvania Senate |
| Termstart2: | 1811 |
| Term End2: | 1815 |
| Office3: | Member of the Pennsylvania House of Representatives |
| Term Start3: | 1803 |
| Term End3: | 1807 |
| Birth Date: | 10 November 1776 |
| Birth Place: | Montgomery County, Pennsylvania |
| Death Place: | Trappe, Pennsylvania |
| Party: | Democratic-Republican |
Samuel Gross (November 10, 1776 – March 19, 1839) was an American politician from Pennsylvania who served as a Republican member of the United States House of Representatives for Pennsylvania's 2nd congressional district from 1819 to 1823.
Born in Upper Providence Township in Montgomery County, Pennsylvania, he engaged in agricultural pursuits. He served as a member of the Pennsylvania House of Representatives 1803–1807; served in the Pennsylvania State Senate 1811–1815; was elected as a Republican to the Sixteenth and Seventeenth Congresses (March 4, 1819 – March 4, 1823). He died in Trappe, Pennsylvania.