| Sainte-Reine | |
| Commune Status: | Commune |
| Coordinates: | 47.4978°N 5.7792°W |
| Insee: | 70471 |
| Postal Code: | 70700 |
| Arrondissement: | Vesoul |
| Canton: | Scey-sur-Saône-et-Saint-Albin |
| Mayor: | Bernard Royer |
| Term: | 2020 - 2026 |
| Elevation Min M: | 214 |
| Elevation Max M: | 254 |
| Area Km2: | 6.18 |
Sainte-Reine (pronounced as /fr/) is a commune in the Haute-Saône department in the region of Bourgogne-Franche-Comté in eastern France.