| Saint-Sernin-du-Plain | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Saint-Sernin-du-Plain 71.svg |
| Insee: | 71480 |
| Postal Code: | 71510 |
| Arrondissement: | Chalon-sur-Saône |
| Canton: | Chagny |
| Intercommunality: | CA Le Grand Chalon |
| Coordinates: | 46.8928°N 4.6192°W |
| Elevation M: | 400 |
| Elevation Min M: | 230 |
| Elevation Max M: | 542 |
| Area Km2: | 14.45 |
Saint-Sernin-du-Plain (pronounced as /fr/) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.