STRN3 explained

Striatin-3 is a protein that in humans is encoded by the STRN3 gene.^{[1] [2] [3]}

Interactions

STRN3 has been shown to interact with:

• CTTNBP2NL,
• CTTNBP2,
• FAM40A,
• MOBKL3,
• PDCD10,^[4]
• PPP2CA,^[4]
• PPP2R1A,^[4]
• RP6-213H19.1,^[4]
• STK24,^{[4] [5]} and
• STRN.^[4]

Further reading

• Landberg G, Tan EM . Characterization of a DNA-binding nuclear autoantigen mainly associated with S phase and G2 cells . Exp. Cell Res. . 212 . 2 . 255–61 . 1994 . 7910562 . 10.1006/excr.1994.1141 .
• Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A . Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain . J. Biol. Chem. . 275 . 26 . 19970–7 . 2000 . 10748158 . 10.1074/jbc.M909782199 . free .
• Moreno CS, Lane WS, Pallas DC . A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes . J. Biol. Chem. . 276 . 26 . 24253–60 . 2001 . 11319234 . 3503316 . 10.1074/jbc.M102398200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A . Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC) . J. Proteome Res. . 5 . 1 . 64–75 . 2006 . 16396496 . 10.1021/pr0502626 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Muro Y, Chan EK, Landberg G, Tan EM . A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells . Biochem. Biophys. Res. Commun. . 207 . 3 . 1029–37 . Mar 1995 . 7864889 . 10.1006/bbrc.1995.1288 .
2. Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC . WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A . J. Biol. Chem. . 275 . 8 . 5257–63 . Mar 2000 . 10681496 . 3505218 . 10.1074/jbc.275.8.5257 . free .
3. Web site: Entrez Gene: STRN3 striatin, calmodulin binding protein 3.
4. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC . A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein . Mol. Cell. Proteomics . 8 . 1 . 157–71 . Jan 2009 . 18782753 . 2621004 . 10.1074/mcp.M800266-MCP200 . free .
5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .