STEAP3 explained
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.[1] [2]
STEAP3 is a metalloreductase, capable of converting iron from an insoluble ferric (Fe3+) to a soluble ferrous (Fe2+) form.[3]
STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ).[4] [5]
Interactions
STEAP3 has been shown to interact with BNIP3L and PKMYT1.[1]
Further reading
- Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
- Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F . Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer . The Journal of Biological Chemistry . 277 . 39 . 36689–96 . September 2002 . 12095985 . 10.1074/jbc.M202414200 . free .
- Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A . TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway . The Journal of Biological Chemistry . 279 . 44 . 46104–12 . October 2004 . 15319436 . 10.1074/jbc.M404850200 . free .
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . October 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S . The LIFEdb database in 2006 . Nucleic Acids Research . 34 . Database issue . D415-8 . January 2006 . 16381901 . 1347501 . 10.1093/nar/gkj139 .
Notes and References
- Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A . The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase . Proceedings of the National Academy of Sciences of the United States of America . 100 . 5 . 2284–9 . March 2003 . 12606722 . 151332 . 10.1073/pnas.0530298100 . 2003PNAS..100.2284P . free .
- Web site: Entrez Gene: STEAP3 STEAP family member 3.
- Ohgami RS, Campagna DR, McDonald A, Fleming MD . The Steap proteins are metalloreductases . Blood . 108 . 4 . 1388–94 . August 2006 . 16609065 . 1785011 . 10.1182/blood-2006-02-003681 .
- Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM . Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle . Proceedings of the National Academy of Sciences of the United States of America . 105 . 21 . 7410–5 . May 2008 . 18495927 . 2396704 . 10.1073/pnas.0801318105 . 2008PNAS..105.7410S . free .
- Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM . The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site . The Journal of Biological Chemistry . 288 . 28 . 20668–82 . July 2013 . 23733181 . 3711330 . 10.1074/jbc.M113.479154 . free .
