STAP1 explained
Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene.[1] [2] [3]
Function
The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.
Interactions
STAP1 has been shown to interact with C19orf2.[4]
Further reading
- Kurosaki T . Genetic analysis of B cell antigen receptor signaling. . Annu. Rev. Immunol. . 17 . 1 . 555–92 . 1999 . 10358768 . 10.1146/annurev.immunol.17.1.555 .
- Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M . Creation of genome-wide protein expression libraries using random activation of gene expression. . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . 25064683 .
- Yokohari K, Yamashita Y, Okada S, Ohya K, Oda S, Hatano M, Mano H, Hirasawa H, Tokuhisa T . Isoform-dependent interaction of BRDG1 with Tec kinase. . Biochem. Biophys. Res. Commun. . 289 . 2 . 414–20 . 2002 . 11716489 . 10.1006/bbrc.2001.6008 .
- Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A . STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. . J. Biol. Chem. . 278 . 13 . 11182–9 . 2003 . 12540842 . 10.1074/jbc.M211230200 . free .
- Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC . Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. . Atherosclerosis . 191 . 1 . 63–72 . 2007 . 16806233 . 10.1016/j.atherosclerosis.2006.05.032 .
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
Notes and References
- Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H . Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase . Proc Natl Acad Sci U S A . 96 . 21 . 11976–81 . Nov 1999 . 10518561 . 18397 . 10.1073/pnas.96.21.11976 . 1999PNAS...9611976O . free .
- Masuhara M, Nagao K, Nishikawa M, Sasaki M, Yoshimura A, Osawa M . Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains . Biochem Biophys Res Commun . 268 . 3 . 697–703 . Mar 2000 . 10679268 . 10.1006/bbrc.2000.2223 .
- Web site: Entrez Gene: BRDG1 BCR downstream signaling 1.
- Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W . Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI . . 302 . 5648 . 1208–12 . Nov 2003 . 14615539 . 10.1126/science.1088401 . 2003Sci...302.1208G . 26836888 .
