ST13 explained

Hsc70-interacting protein also known as suppression of tumorigenicity 13 (ST13) is a protein that in humans is encoded by the ST13 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene.^[3]

Further reading

• Prapapanich V, Chen S, Toran EJ, etal . Mutational analysis of the hsp70-interacting protein Hip . Mol. Cell. Biol. . 16 . 11 . 6200–7 . 1996 . 8887650 . 10.1128/MCB.16.11.6200. 231623 .
• Cao J, Cai X, Zheng L, etal . Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening . J. Cancer Res. Clin. Oncol. . 123 . 8 . 447–51 . 1997 . 9292708 . 10.1007/BF01372549 . 42097617 .
• Mo Y, Zheng S, Shen D . [Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa] . Zhonghua Zhong Liu Za Zhi . 18 . 4 . 241–3 . 1998 . 9387309 .
• Johnson BD, Schumacher RJ, Ross ED, Toft DO . Hop modulates Hsp70/Hsp90 interactions in protein folding . J. Biol. Chem. . 273 . 6 . 3679–86 . 1998 . 9452498 . 10.1074/jbc.273.6.3679 . free .
• Zheng S, Cai X, Cao J, etal . Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes . Chin. Med. J. . 110 . 7 . 543–7 . 1998 . 9594214 .
• Chen S, Smith DF . Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery . J. Biol. Chem. . 273 . 52 . 35194–200 . 1999 . 9857057 . 10.1074/jbc.273.52.35194 . free .
• Scanlan MJ, Gordan JD, Williamson B, etal . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . Int. J. Cancer . 83 . 4 . 456–64 . 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . 21839750 .
• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Morishima Y, Kanelakis KC, Silverstein AM, etal . The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system . J. Biol. Chem. . 275 . 10 . 6894–900 . 2000 . 10702249 . 10.1074/jbc.275.10.6894 . free .
• Rajapandi T, Greene LE, Eisenberg E . The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor . J. Biol. Chem. . 275 . 29 . 22597–604 . 2000 . 10781595 . 10.1074/jbc.M002035200 . free .
• Agarraberes FA, Dice JF . A molecular chaperone complex at the lysosomal membrane is required for protein translocation . J. Cell Sci. . 114 . Pt 13 . 2491–9 . 2002 . 10.1242/jcs.114.13.2491 . 11559757 .
• Velten M, Gomez-Vrielynck N, Chaffotte A, Ladjimi MM . Domain structure of the HSC70 cochaperone, HIP . J. Biol. Chem. . 277 . 1 . 259–66 . 2002 . 11687574 . 10.1074/jbc.M106881200 . free .
• Fan GH, Yang W, Sai J, Richmond A . Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking . J. Biol. Chem. . 277 . 8 . 6590–7 . 2002 . 11751889 . 10.1074/jbc.M110588200 . 2665275 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nelson GM, Prapapanich V, Carrigan PE, etal . The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor . Mol. Endocrinol. . 18 . 7 . 1620–30 . 2005 . 15071092 . 10.1210/me.2004-0054 . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Zhang Y, Cai X, Schlegelberger B, Zheng S . Assignment1 of human putative tumor suppressor genes ST13 (alias SNC6) and ST14 (alias SNC19) to human chromosome bands 22q13 and 11q24→q25 by in situ hybridization . Cytogenet Cell Genet . 83 . 1–2 . 56–7 . Mar 1999 . 9925927 . 10.1159/000015125 . 37163219 .
2. Prapapanich V, Chen S, Nair SC, Rimerman RA, Smith DF . Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein . Mol Endocrinol . 10 . 4 . 420–31 . Oct 1996 . 10.1210/mend.10.4.8721986 . 8721986 . free .
3. Web site: Entrez Gene: ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein).