SSX5 explained

Protein SSX5 is a protein that in humans is encoded by the SSX5 gene.^[1]

Function

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This gene appears not to be involved in this type of translocation. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• dos Santos NR, de Bruijn DR, van Kessel AG . Molecular mechanisms underlying human synovial sarcoma development . Genes, Chromosomes & Cancer . 30 . 1 . 1–14 . January 2001 . 11107170 . 10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G . 24403558 .
• Gure AO, Türeci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT . SSX: a multigene family with several members transcribed in normal testis and human cancer . International Journal of Cancer . 72 . 6 . 965–71 . September 1997 . 9378559 . 10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N . 21203036 .
• Chen CH, Chen GJ, Lee HS, Huang GT, Yang PM, Tsai LJ, Chen DS, Sheu JC . Ding-Shinn Chen . Expressions of cancer-testis antigens in human hepatocellular carcinomas . Cancer Letters . 164 . 2 . 189–95 . March 2001 . 11179834 . 10.1016/S0304-3835(01)00379-2 .
• de Bruijn DR, dos Santos NR, Kater-Baats E, Thijssen J, van den Berk L, Stap J, Balemans M, Schepens M, Merkx G, van Kessel AG . The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP . Genes, Chromosomes & Cancer . 34 . 3 . 285–98 . July 2002 . 12007189 . 10.1002/gcc.10073 . 11734893 .
• Güre AO, Wei IJ, Old LJ, Chen YT . The SSX gene family: characterization of 9 complete genes . International Journal of Cancer . 101 . 5 . 448–53 . October 2002 . 12216073 . 10.1002/ijc.10634 . 21174312 . free .
• Wu LQ, Lu Y, Wang XF, Lv ZH, Zhang B, Yang JY . Expression of cancer-testis antigen (CTA) in tumor tissues and peripheral blood of Chinese patients with hepatocellular carcinoma . Life Sciences . 79 . 8 . 744–8 . July 2006 . 16546222 . 10.1016/j.lfs.2006.02.024 .

Notes and References

1. Web site: Entrez Gene: SSX5 synovial sarcoma, X breakpoint 5.