SPRY4 explained

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.^{[1] [2]}

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).^[2]

Interactions

SPRY4 has been shown to interact with TESK1.^[3]

See also

• MAPK signaling pathway
• Ras subfamily

Further reading

• Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D . Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping . BMC Psychiatry . 8 . 11 . 2008 . 18298822 . 2268687 . 10.1186/1471-244X-8-11 . free .
• Cabrita MA, Jäggi F, Widjaja SP, Christofori G . A functional interaction between sprouty proteins and caveolin-1 . The Journal of Biological Chemistry . 281 . 39 . 29201–12 . Sep 2006 . 16877379 . 10.1074/jbc.M603921200 . free .
• Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B . Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer . The Prostate . 66 . 6 . 613–24 . May 2006 . 16388505 . 10.1002/pros.20353 . 43803094 . free .
• Ding W, Bellusci S, Shi W, Warburton D . Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis . American Journal of Physiology. Lung Cellular and Molecular Physiology . 287 . 1 . L52-9 . Jul 2004 . 14977631 . 10.1152/ajplung.00430.2003 .
• Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A . Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 . Nature Cell Biology . 5 . 5 . 427–32 . May 2003 . 12717443 . 10.1038/ncb978 . 33846459 .
• Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ . Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 . European Journal of Biochemistry . 269 . 10 . 2546–56 . May 2002 . 12027893 . 10.1046/j.1432-1033.2002.02921.x . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)

Notes and References

1. Katoh Y, Katoh M . FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells . International Journal of Molecular Medicine . 17 . 3 . 529–32 . Mar 2006 . 16465403 . 10.3892/ijmm.17.3.529 . free .
2. Web site: Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila).
3. Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ . Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 . European Journal of Biochemistry . 269 . 10 . 2546–56 . May 2002 . 12027893 . 10.1046/j.1432-1033.2002.02921.x . free .