Spondin 2 Explained

Spondin 2, also known as mindin, is a protein that in humans is encoded by the SPON2 gene.^[1]

Further reading

• Yan L, Wei X, Tang QZ, Feng J, Zhang Y, Liu C, Bian ZY, Zhang LF, Chen M, Bai X, Wang AB, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H . Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling . Cardiovascular Research . 92 . 1 . 85–94 . October 2011 . 21632881 . 3657538 . 10.1093/cvr/cvr159 .
• Qian X, Li C, Pang B, Xue M, Wang J, Zhou J . Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker . PLOS ONE . 7 . 5 . e37225 . 2012 . 22615945 . 3352876 . 10.1371/journal.pone.0037225 . 2012PLoSO...737225Q . free .
• Feinstein Y, Klar A . The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities . The International Journal of Biochemistry & Cell Biology . 36 . 6 . 975–80 . June 2004 . 15094111 . 10.1016/j.biocel.2004.01.002 .
• Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, Mariuzza RA . Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule . The EMBO Journal . 28 . 3 . 286–97 . February 2009 . 19153605 . 2637340 . 10.1038/emboj.2008.288 .
• Liao CH, Yeh SC, Huang YH, Chen RN, Tsai MM, Chen WJ, Chi HC, Tai PJ, Liao CJ, Wu SM, Cheng WL, Pai LM, Lin KH . Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion . Endocrine-Related Cancer . 17 . 1 . 99–111 . March 2010 . 19903741 . 10.1677/ERC-09-0050 . free .
• Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Takagi M, Horikoshi S, Tomino Y . Mindin: a novel marker for podocyte injury in diabetic nephropathy . Nephrology, Dialysis, Transplantation . 26 . 7 . 2153–60 . July 2011 . 21098016 . 10.1093/ndt/gfq708 . free .
• Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J . Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display . Genomics . 61 . 1 . 5–14 . October 1999 . 10512675 . 10.1006/geno.1999.5939 .
• Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP . Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes . Physiological Genomics . 25 . 1 . 9–15 . March 2006 . 16368877 . 10.1152/physiolgenomics.00121.2005 .
• Kong A, Thorleifsson G, Stefansson H, Masson G, Helgason A, Gudbjartsson DF, Jonsdottir GM, Gudjonsson SA, Sverrisson S, Thorlacius T, Jonasdottir A, Hardarson GA, Palsson ST, Frigge ML, Gulcher JR, Thorsteinsdottir U, Stefansson K . Sequence variants in the RNF212 gene associate with genome-wide recombination rate . Science . 319 . 5868 . 1398–401 . March 2008 . 18239089 . 10.1126/science.1152422 . 2008Sci...319.1398K . 5975476 .

Notes and References

1. Web site: Entrez Gene: Spondin 2, extracellular matrix protein .