SOX13 explained

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.^{[1] [2]}

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.

In melanocytic cells SOX13 gene expression may be regulated by MITF.^[3]

See also

• SOX genes

Further reading

• Wilson M, Koopman P . Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators . Current Opinion in Genetics & Development . 12 . 4 . 441–6 . Aug 2002 . 12100890 . 10.1016/S0959-437X(02)00323-4 .
• Schepers GE, Teasdale RD, Koopman P . Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families . Developmental Cell . 3 . 2 . 167–70 . Aug 2002 . 12194848 . 10.1016/S1534-5807(02)00223-X . free .
• Roose J, Korver W, Oving E, Wilson A, Wagenaar G, Markman M, Lamers W, Clevers H . High expression of the HMG box factor sox-13 in arterial walls during embryonic development . Nucleic Acids Research . 26 . 2 . 469–76 . Jan 1998 . 9421502 . 147262 . 10.1093/nar/26.2.469 .
• Argentaro A, Olsson J, Critcher R, McDowall SG, Harley VR . Genomic characterisation and fine mapping of the human SOX13 gene . Gene . 250 . 1–2 . 181–9 . May 2000 . 10854791 . 10.1016/S0378-1119(00)00157-8 .
• Kasimiotis H, Myers MA, Argentaro A, Mertin S, Fida S, Ferraro T, Olsson J, Rowley MJ, Harley VR . Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets . Diabetes . 49 . 4 . 555–61 . Apr 2000 . 10871192 . 10.2337/diabetes.49.4.555 . free .
• Steinbrenner H, Lohmann T, Ostendorf B, Scherbaum WA, Seissler J . Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes . Diabetologia . 43 . 11 . 1381–4 . Nov 2000 . 11126406 . 10.1007/s001250051542 . free .
• Kasimiotis H, Fida S, Rowley MJ, Mackay IR, Zimmet PZ, Gleason S, Rabin DU, Myers MA . Antibodies to SOX13 (ICA12) are associated with type 1 diabetes . Autoimmunity . 33 . 2 . 95–101 . 2001 . 11264788 . 10.3109/08916930108995994 . 43867785 .
• Lampasona V, Scirpoli M, Bosi E, Bonifacio E . ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes . Diabetologia . 44 . 2 . 267 . Feb 2001 . 11270687 . 10.1007/s001250051610 . free .
• Argentaro A, Wapelhorst B, Concannon P, Harley VR . Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes . Molecular Genetics and Metabolism . 72 . 4 . 356–9 . Apr 2001 . 11286511 . 10.1006/mgme.2000.3136 .
• Fida S, Myers M, Mackay IR, Zimmet PZ, Mohan V, Deepa R, Rowley MJ . Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13 . Diabetes Research and Clinical Practice . 52 . 3 . 205–11 . Jun 2001 . 11323090 . 10.1016/S0168-8227(01)00230-3 .
• Tandon N, Shtauvere-Brameus A, Hagopian WA, Sanjeevi CB . Prevalence of ICA-12 and other autoantibodies in north Indian patients with early-onset diabetes . Annals of the New York Academy of Sciences . 958 . 214–7 . Apr 2002 . 1 . 12021109 . 10.1111/j.1749-6632.2002.tb02972.x . 2002NYASA.958..214T . 39609924 .
• Törn C, Shtauvere-Brameus A, Sanjeevi CB, Landin-Olsson M . Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes . Annals of the New York Academy of Sciences . 958 . 218–23 . Apr 2002 . 1 . 12021110 . 10.1111/j.1749-6632.2002.tb02973.x . 2002NYASA.958..218T . 38116575 .
• Shtauvere-Brameus A, Hagopian W, Rumba I, Sanjeevi CB . Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients . Annals of the New York Academy of Sciences . 958 . 297–304 . Apr 2002 . 1 . 12021128 . 10.1111/j.1749-6632.2002.tb02991.x . 2002NYASA.958..297S . 26701600 .
• Gupta M, Tandon N, Shtauvere-Brameus A, Sanjeevi CB . ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India . Annals of the New York Academy of Sciences . 958 . 329–32 . Apr 2002 . 1 . 12021135 . 10.1111/j.1749-6632.2002.tb02998.x . 2002NYASA.958..329G . 32027653 .
• Fida S, Myers MA, Whittingham S, Rowley MJ, Ozaki S, Mackay IR . Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases . Journal of Autoimmunity . 19 . 4 . 251–7 . Dec 2002 . 12473246 . 10.1006/jaut.2002.0622 .
• Park Y, Park H, Yoo E, Kim D . SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea . Annals of the New York Academy of Sciences . 1005 . 253–8 . Nov 2003 . 1 . 14679071 . 10.1196/annals.1288.038 . 2003NYASA1005..253P . 11552139 .

Notes and References

1. Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H . The Sox-13 gene: structure, promoter characterization, and chromosomal localization . Genomics . 57 . 2 . 301–5 . Apr 1999 . 10198172 . 10.1006/geno.1999.5779 .
2. Web site: Entrez Gene: SOX13 SRY (sex determining region Y)-box 13.
3. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E . Novel MITF targets identified using a two-step DNA microarray strategy . Pigment Cell & Melanoma Research . 21 . 6 . 665–76 . Dec 2008 . 19067971 . 10.1111/j.1755-148X.2008.00505.x . free .