SOX11 explained

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.^{[1] [2] [3]}

Function

This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.^[4] Tuj1 and Tead2 are suggested as direct target of Sox11.^{[5] [6] [7]}

Clinical aspect

Lymphocyte staining for SOX11 immunohistochemistry indicates mantle cell lymphoma (cyclin D1 positive and negative) rather than other mature lymphoid neoplasms or normal lymphocytes.^[8]

Mutations in SOX11 are associated with Coffin–Siris syndrome^[9] and mantle cell lymphoma.^[10]

See also

• SOX genes

Further reading

• Wilson M, Koopman P . Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators . Current Opinion in Genetics & Development . 12 . 4 . 441–6 . Aug 2002 . 12100890 . 10.1016/S0959-437X(02)00323-4 .
• Schepers GE, Teasdale RD, Koopman P . Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families . Developmental Cell . 3 . 2 . 167–70 . Aug 2002 . 12194848 . 10.1016/S1534-5807(02)00223-X . free .
• Gozé C, Poulat F, Berta P . Partial cloning of SOX-11 and SOX-12, two new human SOX genes . Nucleic Acids Research . 21 . 12 . 2943 . Jun 1993 . 8332506 . 309692 . 10.1093/nar/21.12.2943 .
• Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M . Cooperative function of POU proteins and SOX proteins in glial cells . The Journal of Biological Chemistry . 273 . 26 . 16050–7 . Jun 1998 . 9632656 . 10.1074/jbc.273.26.16050 . free .
• Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M . Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region . DNA Research . 6 . 5 . 357–60 . Oct 1999 . 10574465 . 10.1093/dnares/6.5.357 . free .
• Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ . Differential expression of SOX4 and SOX11 in medulloblastoma . Journal of Neuro-Oncology . 57 . 3 . 201–14 . May 2002 . 12125983 . 10.1023/A:1015773818302 . 20719302 .
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP . Phosphoproteomic analysis of the developing mouse brain . Molecular & Cellular Proteomics . 3 . 11 . 1093–101 . Nov 2004 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM . Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells . Development . 132 . 13 . 3045–54 . Jul 2005 . 15944188 . 10.1242/dev.01890 . free .
• Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F . NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY . The Journal of Biological Chemistry . 280 . 46 . 38625–30 . Nov 2005 . 16166090 . 10.1074/jbc.M504127200 . free .
• DesGroseilliers M, Fortin F, Lemyre E, Lemieux N . Complex mosaicism in sex reversed SRY+ male twins . Cytogenetic and Genome Research . 112 . 1–2 . 176–9 . 2006 . 16276109 . 10.1159/000087532 . 43826181 .

Notes and References

1. Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P . The human SOX11 gene: cloning, chromosomal assignment and tissue expression . Genomics . 29 . 2 . 541–5 . Sep 1995 . 8666406 . 10.1006/geno.1995.9970 .
2. Wiebe MS, Nowling TK, Rizzino A . Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity . The Journal of Biological Chemistry . 278 . 20 . 17901–11 . May 2003 . 12637543 . 10.1074/jbc.M212211200 . free .
3. Web site: Entrez Gene: SOX11 SRY (sex determining region Y)-box 11.
4. Haslinger A, Schwarz TJ, Covic M, Lie DC . Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis . The European Journal of Neuroscience . 29 . 11 . 2103–14 . Jun 2009 . 19490090 . 10.1111/j.1460-9568.2009.06768.x . 42742018 .
5. Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J . The establishment of neuronal properties is controlled by Sox4 and Sox11 . Genes & Development . 20 . 24 . 3475–86 . Dec 2006 . 17182872 . 1698453 . 10.1101/gad.403406 .
6. Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V . Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors . Nature Communications . 1 . 1 . 9 . Apr 2010 . 20596238 . 2892298 . 10.1038/ncomms1008 . 2010NatCo...1....9B .
7. Larson BL, Ylostalo J, Lee RH, Gregory C, Prockop DJ . Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells . Tissue Engineering. Part A . 16 . 11 . 3385–94 . Nov 2010 . 2965191 . 10.1089/ten.tea.2010.0085 . 20626275 .
8. Web site: Stains & CD markers - SOX11. Pathology Outlines. Anna Dusenbery, M.D., Mark R. Wick, M.D.. Topic Completed: 1 January 2018. Minor changes: 12 August 2021
9. Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K, Kodera H, Miyatake S, Nakashima M, Saitsu H, Ogata K, Ikegawa S, Miyake N, Matsumoto N . De novo SOX11 mutations cause Coffin-Siris syndrome . Nature Communications . 5 . 4011 . 2014 . 24886874 . 10.1038/ncomms5011 . 2014NatCo...5.4011T . free .
10. Vose. Julie M.. Mantle cell lymphoma: 2017 update on diagnosis, risk-stratification, and clinical management. American Journal of Hematology. 92. 8. 806–813. August 2017. 10.1002/ajh.24797. 1096-8652. 28699667. free.