SOCS5 explained

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.^{[1] [2]}

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.^[3]

Further reading

• Kile BT, Schulman BA, Alexander WS, etal . The SOCS box: a tale of destruction and degradation . Trends Biochem. Sci. . 27 . 5 . 235–41 . 2002 . 12076535 . 10.1016/S0968-0004(02)02085-6 .
• Wang J, Campbell IL . Cytokine signaling in the brain: putting a SOCS in it? . J. Neurosci. Res. . 67 . 4 . 423–7 . 2002 . 11835308 . 10.1002/jnr.10145 . 33269663 . free .
• Krebs DL, Hilton DJ . SOCS proteins: negative regulators of cytokine signaling . Stem Cells . 19 . 5 . 378–87 . 2001 . 11553846 . 10.1634/stemcells.19-5-378 . 20847942 . free .
• Ozaki A, Seki Y, Fukushima A, Kubo M . The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model . J. Immunol. . 175 . 8 . 5489–97 . 2005 . 16210657 . 10.4049/jimmunol.175.8.5489. free .
• Kario E, Marmor MD, Adamsky K, etal . Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling . J. Biol. Chem. . 280 . 8 . 7038–48 . 2005 . 15590694 . 10.1074/jbc.M408575200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Bayle J, Letard S, Frank R, etal . Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling . J. Biol. Chem. . 279 . 13 . 12249–59 . 2004 . 14707129 . 10.1074/jbc.M313381200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Seki Y, Hayashi K, Matsumoto A, etal . Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation . Proc. Natl. Acad. Sci. U.S.A. . 99 . 20 . 13003–8 . 2002 . 12242343 . 10.1073/pnas.202477099 . 130576 . 2002PNAS...9913003S . free .
• Magrangeas F, Apiou F, Denis S, etal . Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization . Cytogenet. Cell Genet. . 88 . 1–2 . 78–81 . 2000 . 10773671 . 10.1159/000015490 . 19983548 .
• Hilton DJ, Richardson RT, Alexander WS, etal . Twenty proteins containing a C-terminal SOCS box form five structural classes . Proc. Natl. Acad. Sci. U.S.A. . 95 . 1 . 114–9 . 1998 . 9419338 . 10.1073/pnas.95.1.114 . 18144 . 1998PNAS...95..114H . free .

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
3. Web site: Entrez Gene: SOCS5 suppressor of cytokine signaling 5.