SNX26 explained
TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.[1] [2] [3]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined.[4]
Further reading
- Xu Y, Seet LF, Hanson B, Hong W . The Phox homology (PX) domain, a new player in phosphoinositide signalling. . Biochem. J. . 360 . Pt 3 . 513–30 . 2002 . 11736640 . 10.1042/0264-6021:3600513 . 1222253 .
- Dehal P, Predki P, Olsen AS, etal . Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. . Science . 293 . 5527 . 104–11 . 2001 . 11441184 . 10.1126/science.1060310 . 826987 .
- Teasdale RD, Loci D, Houghton F, etal . A large family of endosome-localized proteins related to sorting nexin 1. . Biochem. J. . 358 . Pt 1 . 7–16 . 2001 . 11485546 . 10.1042/0264-6021:3580007 . 1222026 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Chiang SH, Hwang J, Legendre M, etal . TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. . EMBO J. . 22 . 11 . 2679–91 . 2003 . 12773384 . 10.1093/emboj/cdg262 . 156759 .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Liu H, Nakazawa T, Tezuka T, Yamamoto T . Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP. . J. Biol. Chem. . 281 . 33 . 23611–9 . 2006 . 16777849 . 10.1074/jbc.M511205200 . free .
Notes and References
- Peck J, ((Douglas G IV)), Wu CH, Burbelo PD . Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships . FEBS Lett . 528 . 1–3 . 27–34 . Sep 2002 . 12297274 . 10.1016/S0014-5793(02)03331-8 . 30443852 .
- Worby CA, Dixon JE . Sorting out the cellular functions of sorting nexins . Nat Rev Mol Cell Biol . 3 . 12 . 919–31 . Dec 2002 . 12461558 . 10.1038/nrm974 . 36361630 .
- Web site: Entrez Gene: SNX26 sorting nexin 26.
- Web site: Entrez Gene: SNX26 sorting nexin 26.