SNX15 explained

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.^{[1] [2]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membranee to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.^[3]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Guru SC, Agarwal SK, Manickam P, etal . A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus . Genome Res. . 7 . 7 . 725–35 . 1997 . 9253601 . 10.1101/gr.7.7.725 . 310681 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Phillips SA, Barr VA, Haft DH, etal . Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking . J. Biol. Chem. . 276 . 7 . 5074–84 . 2001 . 11085978 . 10.1074/jbc.M004671200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Barr VA, Phillips SA, Taylor SI, Haft CR . Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking . Traffic . 1 . 11 . 904–16 . Mar 2001 . 11208079 . 10.1034/j.1600-0854.2000.011109.x . 31092568 .
2. Web site: Entrez Gene: SNX15 sorting nexin 15.
3. Web site: Entrez Gene: SNX15 sorting nexin 15.