SNRPD3 explained

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.

Interactions

SNRPD3 has been shown to interact with:

• CDC5L,^[4]
• CLNS1A,^[5]
• DDX20,^[6] and
• Protein arginine methyltransferase 5.^[5]

Further reading

• Liu Q, Fischer U, Wang F, Dreyfuss G . The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins . Cell . 90 . 6 . 1013–21 . 1997 . 9323129 . 10.1016/S0092-8674(00)80367-0 . free .
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW . Multiple protein: protein interactions between the snRNP common core proteins . Exp. Cell Res. . 237 . 1 . 63–9 . 1998 . 9417867 . 10.1006/excr.1997.3750 .
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K . Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs . Cell . 96 . 3 . 375–87 . 1999 . 10025403 . 10.1016/S0092-8674(00)80550-4 . free .
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G . Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems . J. Cell Biol. . 147 . 6 . 1181–94 . 2000 . 10601333 . 2168095 . 10.1083/jcb.147.6.1181 .
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G . Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli . J. Cell Biol. . 148 . 6 . 1177–86 . 2000 . 10725331 . 2174312 . 10.1083/jcb.148.6.1177 .
• Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R . The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies . J. Biol. Chem. . 275 . 22 . 17122–9 . 2000 . 10747894 . 10.1074/jbc.M000300200 . free . 11858/00-001M-0000-0012-F7F0-E . free .
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . EMBO J. . 19 . 23 . 6569–81 . 2001 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .
• Urlaub H, Raker VA, Kostka S, Lührmann R . Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure . EMBO J. . 20 . 1–2 . 187–96 . 2001 . 11226169 . 140196 . 10.1093/emboj/20.1.187 .
• Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G . SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets . Mol. Cell . 7 . 5 . 1111–7 . 2001 . 11389857 . 10.1016/S1097-2765(01)00244-1 . free .
• Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G . The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins . Mol. Cell. Biol. . 21 . 24 . 8289–300 . 2001 . 11713266 . 99994 . 10.1128/MCB.21.24.8289-8300.2001 .
• Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G . Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins . J. Biol. Chem. . 277 . 7 . 5631–6 . 2002 . 11714716 . 10.1074/jbc.M109448200 . free .
• Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U . Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln . Curr. Biol. . 11 . 24 . 1990–4 . 2002 . 11747828 . 10.1016/S0960-9822(01)00592-9 . 11858/00-001M-0000-0012-F501-7 . 14742376 . free .
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G . Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component . J. Biol. Chem. . 277 . 9 . 7540–5 . 2002 . 11748230 . 10.1074/jbc.M110141200 . free .
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G . A novel WD repeat protein component of the methylosome binds Sm proteins . J. Biol. Chem. . 277 . 10 . 8243–7 . 2002 . 11756452 . 10.1074/jbc.M109984200 . free .
• Fong YW, Zhou Q . Stimulatory effect of splicing factors on transcriptional elongation . Nature . 414 . 6866 . 929–33 . 2002 . 11780068 . 10.1038/414929a . 1518837 .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . free .
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 1370266 . 10.1017/S1355838202021088 .
• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G . Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex . J. Biol. Chem. . 277 . 35 . 31957–62 . 2002 . 12065586 . 10.1074/jbc.M203478200 . free .

Notes and References

1. Lehmeier T, Foulaki K, Lührmann R . Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5 . Nucleic Acids Res . 18 . 22 . 6475–84 . January 1991 . 1701240 . 332598 . 10.1093/nar/18.22.6475 .
2. Lehmeier T, Raker V, Hermann H, Lührmann R . cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction . Proc Natl Acad Sci U S A . 91 . 25 . 12317–21 . January 1995 . 7527560 . 45428 . 10.1073/pnas.91.25.12317 . 1994PNAS...9112317L . free .
3. Web site: Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa.
4. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . EMBO J. . 19 . 23 . 6569–81 . Dec 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .
5. Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G . The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins . Mol. Cell. Biol. . 21 . 24 . 8289–300 . Dec 2001 . 11713266 . 99994 . 10.1128/MCB.21.24.8289-8300.2001 .
6. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G . Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems . J. Cell Biol. . 147 . 6 . 1181–94 . Dec 1999 . 10601333 . 2168095 . 10.1083/jcb.147.6.1181.