SNRPB explained

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.^{[1] [2]}

Function

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.

Interactions

SNRPB has been shown to interact with DDX20^[3] and Coilin.^[4]

Further reading

• Will CL, Lührmann R . Spliceosomal UsnRNP biogenesis, structure and function . Curr. Opin. Cell Biol. . 13 . 3 . 290–301 . 2001 . 11343899 . 10.1016/S0955-0674(00)00211-8 . 11858/00-001M-0000-0012-F770-0 . free .
• Schmauss C, Lerner MR . The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures . J. Biol. Chem. . 265 . 18 . 10733–9 . 1990 . 10.1016/S0021-9258(18)87008-9 . 1693924 . free .
• Elkon KB, Hines JJ, Chu JL, Parnassa A . Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction . J. Immunol. . 145 . 2 . 636–43 . 1990 . 10.4049/jimmunol.145.2.636 . 1694885 . free .
• Chu JL, Elkon KB . The small nuclear ribonucleoproteins, SmB and B', are products of a single gene . Gene . 97 . 2 . 311–2 . 1991 . 1825643 . 10.1016/0378-1119(91)90069-N .
• Sharpe NG, Williams DG, Latchman DS . Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation . Mol. Cell. Biol. . 10 . 12 . 6817–20 . 1990 . 2174118 . 362965 . 10.1128/mcb.10.12.6817.
• Schmauss C, McAllister G, Ohosone Y, Hardin JA, Lerner MR . A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B' . Nucleic Acids Res. . 17 . 4 . 1733–43 . 1989 . 2522186 . 331831 . 10.1093/nar/17.4.1733 .
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW . Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles . J. Biol. Chem. . 264 . 10 . 5776–83 . 1989 . 10.1016/S0021-9258(18)83617-1 . 2522439 . free .
• Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA . Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles . Proc. Natl. Acad. Sci. U.S.A. . 86 . 11 . 4249–53 . 1989 . 2524838 . 287428 . 10.1073/pnas.86.11.4249 . 1989PNAS...86.4249O . free .
• van Dam A, Winkel I, Zijlstra-Baalbergen J, Smeenk R, Cuypers HT . Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part . EMBO J. . 8 . 12 . 3853–60 . 1989 . 2531083 . 402073 . 10.1002/j.1460-2075.1989.tb08563.x.
• Huntriss JD, Latchman DS, Williams DG . Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B' . Clin. Exp. Immunol. . 92 . 2 . 263–7 . 1993 . 7683587 . 1554819 . 10.1111/j.1365-2249.1993.tb03390.x .
• Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N, Latchman DS . The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein . J. Mol. Cell. Cardiol. . 25 . 3 . 321–9 . 1993 . 8510173 . 10.1006/jmcc.1993.1038 .
• Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V . PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb . Oncogene . 14 . 2 . 145–55 . 1997 . 9010216 . 10.1038/sj.onc.1200825 . free .
• Liu Q, Fischer U, Wang F, Dreyfuss G . The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins . Cell . 90 . 6 . 1013–21 . 1997 . 9323129 . 10.1016/S0092-8674(00)80367-0 . 10855404 . free .
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW . Multiple protein: protein interactions between the snRNP common core proteins . Exp. Cell Res. . 237 . 1 . 63–9 . 1997 . 9417867 . 10.1006/excr.1997.3750 .
• Bedford MT, Reed R, Leder P . WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif . Proc. Natl. Acad. Sci. U.S.A. . 95 . 18 . 10602–7 . 1998 . 9724750 . 27941 . 10.1073/pnas.95.18.10602 . 1998PNAS...9510602B . free .
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K . Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs . Cell . 96 . 3 . 375–87 . 1999 . 10025403 . 10.1016/S0092-8674(00)80550-4 . 17379935 . free .
• Gray TA, Smithwick MJ, Schaldach MA, Martone DL, Graves JA, McCarrey JR, Nicholls RD . Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci . Nucleic Acids Res. . 27 . 23 . 4577–84 . 1999 . 10556313 . 148745 . 10.1093/nar/27.23.4577 .
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G . Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems . J. Cell Biol. . 147 . 6 . 1181–94 . 1999 . 10601333 . 2168095 . 10.1083/jcb.147.6.1181 .
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G . Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli . J. Cell Biol. . 148 . 6 . 1177–86 . 2000 . 10725331 . 2174312 . 10.1083/jcb.148.6.1177 .

Notes and References

1. Griffith AJ, Schmauss C, Craft J . The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site . Gene . 114 . 2 . 195–201 . July 1992 . 1376292 . 10.1016/0378-1119(92)90574-9 .
2. Web site: Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1.
3. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G . Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems . J. Cell Biol. . 147 . 6 . 1181–94 . Dec 1999 . 10601333 . 2168095 . 10.1083/jcb.147.6.1181 .
4. Hebert MD, Szymczyk PW, Shpargel KB, Matera AG . Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein . Genes Dev. . 15 . 20 . 2720–9 . October 2001 . 11641277 . 312817 . 10.1101/gad.908401 .