SNAP-94847 explained

SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH₁. In animal studies it has been shown to produce both anxiolytic and antidepressant effects,^{[1] [2]} and also reduces food consumption suggesting a possible anorectic effect.^[3]

Notes and References

1. David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R . Efficacy of the MCHR1 antagonist N-[3-(1-<nowiki/>{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis . The Journal of Pharmacology and Experimental Therapeutics . 321 . 1 . 237–48 . April 2007 . 17237257 . 10.1124/jpet.106.109678 . 717425 .
2. Smith DG, Hegde LG, Wolinsky TD, Miller S, Papp M, Ping X, Edwards T, Gerald CP, Craig DA . The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents . Behavioural Brain Research . 197 . 2 . 284–91 . February 2009 . 18793675 . 10.1016/j.bbr.2008.08.026 . 205878561 .
3. Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y . Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats . Psychopharmacology . 205 . 1 . 129–40 . July 2009 . 19340414 . 10.1007/s00213-009-1523-6 . 3143407.