Sodium-coupled neutral amino acid transporter 2 explained

Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the SLC38A2 gene.^{[1] [2] [3]}

See also

• Solute carrier family

Further reading

• Nagase T, Kikuno R, Ishikawa KI, etal . Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 7 . 1 . 65–73 . 2000 . 10718198 . 10.1093/dnares/7.1.65 . free .
• Hatanaka T, Huang W, Wang H, etal . Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. . Biochim. Biophys. Acta . 1467 . 1 . 1–6 . 2000 . 10930503 . 10.1016/S0005-2736(00)00252-2 .
• Freeman TL, Thiele GM, Tuma DJ, etal . ATA2-mediated amino acid uptake following partial hepatectomy is regulated by redistribution to the plasma membrane. . Arch. Biochem. Biophys. . 400 . 2 . 215–22 . 2002 . 12054432 . 10.1016/S0003-9861(02)00006-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Palii SS, Chen H, Kilberg MS . Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. . J. Biol. Chem. . 279 . 5 . 3463–71 . 2004 . 14623874 . 10.1074/jbc.M310483200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Franchi-Gazzola R, Gaccioli F, Bevilacqua E, etal . The synthesis of SNAT2 transporters is required for the hypertonic stimulation of system A transport activity. . Biochim. Biophys. Acta . 1667 . 2 . 157–66 . 2005 . 15581851 . 10.1016/j.bbamem.2004.09.012 .
• Bevilacqua E, Bussolati O, Dall'Asta V, etal . SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress. . FEBS Lett. . 579 . 16 . 3376–80 . 2005 . 15922329 . 10.1016/j.febslet.2005.05.002 . 30690140 . free .
• Zhang Y, Wolf-Yadlin A, Ross PL, etal . Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. . Mol. Cell. Proteomics . 4 . 9 . 1240–50 . 2005 . 15951569 . 10.1074/mcp.M500089-MCP200 . free .
• Novak D, Quiggle F, Haafiz A . Impact of forskolin and amino acid depletion upon System A activity and SNAT expression in BeWo cells. . Biochimie . 88 . 1 . 39–44 . 2006 . 16125834 . 10.1016/j.biochi.2005.07.002 .
• Palii SS, Thiaville MM, Pan YX, etal . Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. . Biochem. J. . 395 . 3 . 517–27 . 2006 . 16445384 . 10.1042/BJ20051867 . 1462688 .
• Melone M, Varoqui H, Erickson JD, Conti F . Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex. . Neuroscience . 140 . 1 . 281–92 . 2006 . 16616430 . 10.1016/j.neuroscience.2006.02.042 . 10542427 .
• Gaccioli F, Huang CC, Wang C, etal . Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation. . J. Biol. Chem. . 281 . 26 . 17929–40 . 2006 . 16621798 . 10.1074/jbc.M600341200 . free .
• Jones HN, Ashworth CJ, Page KR, McArdle HJ . Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). . Am. J. Physiol. Endocrinol. Metab. . 291 . 3 . E596–603 . 2006 . 16621896 . 10.1152/ajpendo.00359.2005 . 11068094 .

Notes and References

1. Sugawara M, Nakanishi T, Fei YJ, Huang W, Ganapathy ME, Leibach FH, Ganapathy V . Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A . J Biol Chem . 275 . 22 . 16473–7 . Jul 2000 . 10747860 . 10.1074/jbc.C000205200 . free .
2. Zhang Z, Grewer C . The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates . Biophys J . 92 . 7 . 2621–32 . Mar 2007 . 17237199 . 1864845 . 10.1529/biophysj.106.100776 . 2007BpJ....92.2621Z .
3. Web site: Entrez Gene: SLC38A2 solute carrier family 38, member 2.