SLC35C2 explained

Solute carrier family 35 member C2 is a protein that in humans is encoded by the SLC35C2 gene.^{[1] [2] [3]}

Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.^[3]

Further reading

• Lash GE, Postovit LM, Matthews NE, etal . Oxygen as a regulator of cellular phenotypes in pregnancy and cancer. . Can. J. Physiol. Pharmacol. . 80 . 2 . 103–9 . 2002 . 11934252 . 10.1139/y02-008 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Pires Martins R, Leach RE, Krawetz SA . Whole-body gene expression by data mining. . Genomics . 72 . 1 . 34–42 . 2001 . 11247664 . 10.1006/geno.2000.6437 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Leach R, Duniec-Dmuchowski Z, Tanaka T, etal . Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1→q13.2 by fluorescent in situ hybridization. . Cytogenet. Cell Genet. . 94 . 3–4 . 252–3 . 2002 . 11856893 . 10.1159/000048828 . 33594704 .
• Leach RE, Duniec-Dmuchowski ZM, Pesole G, etal . Identification, molecular characterization, and tissue expression of OVCOV1. . Mamm. Genome . 13 . 11 . 619–24 . 2003 . 12461647 . 10.1007/s00335-002-2185-4 . 19423578 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
2. Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW . A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 . Genomics . 76 . 1–3 . 45–57 . Sep 2001 . 11549316 . 10.1006/geno.2001.6584 .
3. Web site: Entrez Gene: SLC35C2 solute carrier family 35, member C2.