SLC26A8 explained
Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.[1] [2] [3]
Function
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.[3]
Interactions
SLC26A8 has been shown to interact with RACGAP1.[4]
Further reading
- Markovich D . Physiological roles and regulation of mammalian sulfate transporters . Physiol. Rev. . 81 . 4 . 1499–533 . 2001 . 11581495 . 10.1152/physrev.2001.81.4.1499. 30942862 .
- Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J . Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure . Mol. Hum. Reprod. . 11 . 2 . 129–32 . 2005 . 15579655 . 10.1093/molehr/gah140 . free .
- Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G . Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling . J. Biol. Chem. . 276 . 23 . 20309–15 . 2001 . 11278976 . 10.1074/jbc.M011740200 . free .
Notes and References
- Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J . Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 . J. Biol. Chem. . 277 . 16 . 14246–54 . Apr 2002 . 11834742 . 10.1074/jbc.M111802200 . free .
- Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP . Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney . Genomics . 79 . 2 . 249–56 . Feb 2002 . 11829495 . 10.1006/geno.2002.6689 .
- Web site: Entrez Gene: SLC26A8 solute carrier family 26, member 8.
- Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G . Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling . J. Biol. Chem. . 276 . 23 . 20309–15 . Jun 2001 . 11278976 . 10.1074/jbc.M011740200 . free .
