SLC22A18 explained

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.^{[1] [2] [3]}

Function

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.

See also

• Solute carrier family

Further reading

• Akiyama S . [Mechanisms of drug resistance and reversal of the resistance] . Human Cell . 14 . 4 . 257–60 . December 2001 . 11925925 .
• Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, Reece M, Prawitt D, Landers J, Housman DE, Winterpacht A, Zabel BU, Pelletier J, Weissman BE, Shows TB, Higgins MJ . Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain . Genomics . 49 . 1 . 38–51 . April 1998 . 9570947 . 10.1006/geno.1998.5221 .
• Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J . Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules . FEBS Letters . 433 . 3 . 245–50 . August 1998 . 9744804 . 10.1016/S0014-5793(98)00907-7 . 6967408 . free . 1998FEBSL.433..245R .
• Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu RJ, Brandenburg S, Lee MJ, Miller G, Feinberg AP . Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5 . Cancer Research . 58 . 18 . 4155–9 . September 1998 . 9751628 .
• Morisaki H, Hatada I, Morisaki T, Mukai T . A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice . DNA Research . 5 . 4 . 235–40 . August 1998 . 9802569 . 10.1093/dnares/5.4.235 . 10.1.1.505.8561 .
• Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP . Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain . Genome Research . 10 . 11 . 1697–710 . November 2000 . 11076855 . 10.1101/gr.161800 . free .
• Yamada HY, Gorbsky GJ . Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 . Oncogene . 25 . 9 . 1330–9 . March 2006 . 16314844 . 2713668 . 10.1038/sj.onc.1209167 .
• Gallagher E, Mc Goldrick A, Chung WY, Mc Cormack O, Harrison M, Kerin M, Dervan PA, Mc Cann A . Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer . Genomics . 88 . 1 . 12–7 . July 2006 . 16624517 . 10.1016/j.ygeno.2006.02.004 .

Notes and References

1. Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B . IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes . Human Molecular Genetics . 7 . 4 . 597–608 . April 1998 . 9499412 . 10.1093/hmg/7.4.597 . free .
2. Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M . Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples . Proceedings of the National Academy of Sciences of the United States of America . 95 . 7 . 3873–8 . March 1998 . 9520460 . 19930 . 10.1073/pnas.95.7.3873 . 1998PNAS...95.3873S . free .
3. Web site: Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18.