SHC2 explained

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.^{[1] [2] [3]}

Interactions

SHC2 has been shown to interact with Kinase insert domain receptor.^[4]

Further reading

• Choy KW, Wang CC, Ogura A, etal . Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. . Physiol. Genomics . 25 . 1 . 9–15 . 2007 . 16368877 . 10.1152/physiolgenomics.00121.2005 .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Liu HY . Meakin SO . ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. . J. Biol. Chem. . 277 . 29 . 26046–56 . 2002 . 12006576 . 10.1074/jbc.M111659200 . free .
• Warner AJ, Lopez-Dee J, Knight EL, etal . The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells. . Biochem. J. . 347 . Pt 2 . 501–9 . 2001 . 10749680 . 10.1042/0264-6021:3470501. 1220983 .
• Pelicci G, Dente L, De Giuseppe A, etal . A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. . Oncogene . 13 . 3 . 633–41 . 1996 . 8760305 .

Notes and References

1. Kavanaugh WM . Williams LT . An alternative to SH2 domains for binding tyrosine-phosphorylated proteins . Science . 266 . 5192 . 1862–5 . Jan 1995 . 7527937 . 10.1126/science.7527937 . 1994Sci...266.1862K .
2. Nakamura T . Muraoka S . Sanokawa R . Mori N . N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling . J Biol Chem . 273 . 12 . 6960–7 . Apr 1998 . 9507002 . 10.1074/jbc.273.12.6960 . free .
3. Web site: Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2.
4. 10.1042/0264-6021:3470501 . Warner . A J . Lopez-Dee J . Knight E L . Feramisco J R . Prigent S A . Apr 2000 . The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells . Biochem. J. . 347 . Pt 2 . 501–9 . England. 0264-6021. 10749680 . 1220983 .