SGK2 explained

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.^{[1] [2]}

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.

Further reading

• Lang F, Cohen P . Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms . Sci. STKE . 2001 . 108 . RE17 . 2002 . 11707620 . 10.1126/stke.2001.108.re17 . 25927734 .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . vanc. Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Gamper N . K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK . Pflügers Arch. . 445 . 1 . 60–6 . 2003 . 12397388 . 10.1007/s00424-002-0873-2 . vanc. Fillon S . Feng Y . 3 . b. . Friedrich . p. . Lang . g. . Henke . s. . Huber . t. . Kobayashi . p. . Cohen . 21073737 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Friedrich B . The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC . Pflügers Arch. . 445 . 6 . 693–6 . 2003 . 12632189 . 10.1007/s00424-002-0993-8 . vanc. Feng Y . Cohen P . 3 . Risler . T . Vandewalle . A . Bröer . S . Wang . J . Pearce . D . Lang . F . 32511608 .
• Embark HM . Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms . Pflügers Arch. . 445 . 5 . 601–6 . 2003 . 12634932 . 10.1007/s00424-002-0982-y . vanc. Böhmer C . Vallon V . 3 . Luft . F . Lang . F . 22981271 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Baltaev R . Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes . Pflügers Arch. . 450 . 1 . 26–33 . 2005 . 15578212 . 10.1007/s00424-004-1369-z . vanc. Strutz-Seebohm N . Korniychuk G . 3 . Myssina . Svetlana . Lang . Florian . Seebohm . Guiscard . 190895 .
• Cheng J . Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution . Science . 308 . 5725 . 1149–54 . 2005 . 15790807 . 10.1126/science.1108625 . vanc. Kapranov P . Drenkow J . 3 . Dike . S . Brubaker . S . Patel . S . Long . J . Stern . D . Tammana . H . 2005Sci...308.1149C . 13047538 .

Notes and References

1. Kobayashi T, Deak M, Morrice N, Cohen P . Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase . Biochem J . 344 . 1. 189–97 . Jan 2000 . 10548550 . 1220630 . 10.1042/0264-6021:3440189.
2. Web site: Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2.