SERPINE2 explained

Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.^{[1] [2]}

See also

• Serpin

Further reading

• Naldini L . Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor . EMBO J. . 11 . 13 . 4825–33 . 1993 . 1334458 . 10.1002/j.1460-2075.1992.tb05588.x. 556958 . vanc. Tamagnone L . Vigna E . 3 . Sachs . M . Hartmann . G . Birchmeier . W . Daikuhara . Y . Tsubouchi . H . Blasi . F .
• Gloor S . A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins . Cell . 47 . 5 . 687–93 . 1987 . 2877744 . 10.1016/0092-8674(86)90511-8 . vanc. Odink K . Guenther J . 3 . Nick . Hanspeter . Monard . Denis . 35327577 .
• Sommer J . cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily . Biochemistry . 26 . 20 . 6407–10 . 1988 . 3427015 . 10.1021/bi00394a016 . vanc. Gloor SM . Rovelli GF . 3 . Hofsteenge . Jan . Nick . Hanspeter . Meier . Roland . Monard . Denis .
• Scott RW . Protease nexin. Properties and a modified purification procedure . J. Biol. Chem. . 260 . 11 . 7029–34 . 1985 . 3997857 . vanc. Bergman BL . Bajpai A . 3 . Hersh . RT . Rodriguez . H . Jones . BN . Barreda . C . Watts . S . Baker . JB . 10.1016/S0021-9258(18)88883-4 . free .
• Magnaldo T, Bernerd F, Darmon M . Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid . Dev. Biol. . 168 . 2 . 259–71 . 1995 . 7729568 . 10.1006/dbio.1995.1078 . free .
• Donovan FM, Vaughan PJ, Cunningham DD . Regulation of protease nexin-1 target protease specificity by collagen type IV . J. Biol. Chem. . 269 . 25 . 17199–205 . 1994 . 10.1016/S0021-9258(17)32540-1 . 8006028 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Nykjaer A . Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes . EMBO J. . 16 . 10 . 2610–20 . 1997 . 9184208 . 10.1093/emboj/16.10.2610 . 1169872 . vanc. Conese M . Christensen EI . 3 . Olson . D . Cremona . O . Gliemann . J . Blasi . F .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . Akira . Sugano . Sumio .
• Li Y, Lu YY . Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells . World J. Gastroenterol. . 8 . 2 . 213–6 . 2002 . 11925594 . 10.3748/wjg.v8.i2.213 . 4658353 . free .
• Grabham PW, Monard D, Gallimore PH, Grand RJ . Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin . The European Journal of Neuroscience. 3 . 7 . 663–668 . 1991. 12106474 . 10.1111/j.1460-9568.1991.tb00852.x . 216379 .
• Crisp RJ, Knauer MF, Knauer DJ . Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV . J. Biol. Chem. . 277 . 49 . 47285–91 . 2003 . 12356769 . 10.1074/jbc.M204813200 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Petrovic D . Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction . Acta Neurol. Scand. . 108 . 2 . 109–13 . 2003 . 12859287 . 10.1034/j.1600-0404.2003.00126.x . vanc. Milanez T . Kobal J . 3 . Bregar . D. . Potisk . K. P. . Peterlin . B. . 25978032 . free.
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Kim JA . Brain endothelial hemostasis regulation by pericytes . J. Cereb. Blood Flow Metab. . 26 . 2 . 209–17 . 2006 . 16015279 . 10.1038/sj.jcbfm.9600181 . vanc. Tran ND . Li Z . 3 . Yang . Fan . Zhou . Weilin . Fisher . Mark J . free.
• Navaneetham D . Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2 . J. Biol. Chem. . 280 . 43 . 36165–75 . 2006 . 16085935 . 10.1074/jbc.M504990200 . vanc. Jin L . Pandey P . 3 . Strickler . JE . Babine . RE . Abdel-Meguid . SS . Walsh . PN . free .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

External links

• The MEROPS online database for peptidases and their inhibitors: I04.021

Notes and References

1. Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW . The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes . Genomics . 27 . 1 . 196–9 . Oct 1995 . 7665170 . 10.1006/geno.1995.1025 .
2. Web site: Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2.