SBF1 explained

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.^{[1] [2] [3]}

Interactions

SBF1 has been shown to interact with MTMR2^[4] and SUV39H1.^[5]

Further reading

• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Firestein R, Cui X, Huie P, Cleary ML . Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9 . Mol. Cell. Biol. . 20 . 13 . 4900–9 . 2000 . 10848615 . 85941 . 10.1128/MCB.20.13.4900-4909.2000 .
• Firestein R, Cleary ML . Pseudo-phosphatase Sbf1 contains an N-terminal GEF homology domain that modulates its growth regulatory properties . J. Cell Sci. . 114 . Pt 16 . 2921–7 . 2001 . 10.1242/jcs.114.16.2921 . 11686296 .
• Firestein R, Nagy PL, Daly M, Huie P, Conti M, Cleary ML . Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1 . J. Clin. Invest. . 109 . 9 . 1165–72 . 2002 . 11994405 . 150957 . 10.1172/JCI12589 .
• Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE . Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4492–7 . 2003 . 12668758 . 153583 . 10.1073/pnas.0431052100 . 2003PNAS..100.4492K . free .

Notes and References

1. Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML . Association of SET domain and myotubularin-related proteins modulates growth control . Nat. Genet. . 18 . 4 . 331–7 . April 1998 . 9537414 . 10.1038/ng0498-331 . 25209204 .
2. Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL . Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human . Hum. Mol. Genet. . 7 . 11 . 1703–12 . December 1998 . 9736772 . 10.1093/hmg/7.11.1703 . free .
3. Web site: Entrez Gene: SBF1 SET binding factor 1.
4. Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE . Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4492–7 . April 2003 . 12668758 . 153583 . 10.1073/pnas.0431052100 . 2003PNAS..100.4492K . free .
5. Firestein R, Cui X, Huie P, Cleary ML . Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9 . Mol. Cell. Biol. . 20 . 13 . 4900–9 . July 2000 . 10848615 . 85941 . 10.1128/MCB.20.13.4900-4909.2000 .