SAA2 explained

Serum amyloid A protein is a protein that in humans is encoded by the SAA2 gene.^{[1] [2]}

Further reading

• Betts JC, Edbrooke MR, Thakker RV, Woo P . The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells. . Scand. J. Immunol. . 34 . 4 . 471–82 . 1991 . 1656519 . 10.1111/j.1365-3083.1991.tb01570.x . 26076389 .
• Zimlichman S . Serum amyloid A, an acute phase protein, inhibits platelet activation . J. Lab. Clin. Med. . 116 . 2 . 180–6 . 1990 . 1697614 . Danon A . Nathan I . Mozes . G . Shainkin-Kestenbaum . R .
• Steinkasserer A, Weiss EH, Schwaeble W, Linke RP . Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis . Biochem. J. . 268 . 1 . 187–93 . 1990 . 1971508 . 10.1042/bj2680187. 1131410 .
• Woo P, Sipe J, Dinarello CA, Colten HR . Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells . J. Biol. Chem. . 262 . 32 . 15790–5 . 1987 . 10.1016/S0021-9258(18)47798-8 . 2890635 . free .
• Kluve-Beckerman B, Dwulet FE, Benson MD . Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person . J. Clin. Invest. . 82 . 5 . 1670–5 . 1988 . 3183061 . 10.1172/JCI113779 . 442736 .
• Kluve-Beckerman B, Long GL, Benson MD . DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA) . Biochem. Genet. . 24 . 11–12 . 795–803 . 1987 . 3800865 . 10.1007/BF00554519 . 8124689 .
• Meek RL, Hoffman JS, Benditt EP . Amyloidogenesis. One serum amyloid A isotype is selectively removed from the circulation . J. Exp. Med. . 163 . 3 . 499–510 . 1986 . 3950541 . 10.1084/jem.163.3.499 . 2188051 .
• Badolato R . Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes . J. Exp. Med. . 180 . 1 . 203–9 . 1994 . 7516407 . 10.1084/jem.180.1.203 . 2191543 . Wang JM . Murphy WJ . Lloyd . AR . Michiel . DF . Bausserman . LL . Kelvin . DJ . Oppenheim . JJ .
• Badolato R . Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway . J. Immunol. . 155 . 8 . 4004–10 . 1995 . 7561109 . Johnston JA . Wang JM . McVicar . D . Xu . LL . Oppenheim . JJ . Kelvin . DJ . 10.4049/jimmunol.155.8.4004 . free .
• Xu L . A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion . J. Immunol. . 155 . 3 . 1184–90 . 1995 . 7636186 . Badolato R . Murphy WJ . Longo . DL . Anver . M . Hale . S . Oppenheim . JJ . Wang . JM . 10.4049/jimmunol.155.3.1184 . free .
• Liepnieks JJ, Kluve-Beckerman B, Benson MD . Characterization of amyloid A protein in human secondary amyloidosis: the predominant deposition of serum amyloid A1 . Biochim. Biophys. Acta . 1270 . 1 . 81–6 . 1995 . 7827140 . 10.1016/0925-4439(94)00076-3. free .
• Arai K, Miura K, Baba S, Shirasawa H . Transformation from SAA2-fibrils to AA-fibrils in amyloid fibrillogenesis: in vivo observations in murine spleen using anti-SAA and anti-AA antibodies . J. Pathol. . 173 . 2 . 127–34 . 1994 . 8089807 . 10.1002/path.1711730209 . 10271/1458 . 1125165 . free .
• Meek RL, Urieli-Shoval S, Benditt EP . Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function . Proc. Natl. Acad. Sci. U.S.A. . 91 . 8 . 3186–90 . 1994 . 8159722 . 10.1073/pnas.91.8.3186 . 43540 . 1994PNAS...91.3186M . free .
• Sellar GC . The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis . Genomics . 19 . 2 . 221–7 . 1994 . 8188252 . 10.1006/geno.1994.1051 . Jordan SA . Bickmore WA . Fantes . Judy A. . Van Heyningen . Veronica . Whitehead . Alexander S. .
• Ducret A . Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry . Electrophoresis . 17 . 5 . 866–76 . 1996 . 8783012 . 10.1002/elps.1150170508 . Bruun CF . Bures EJ . Marhaug . Gudmund . Husby . Gunnar . Aebersold . Ruedi . 35332525 .
• Ancsin JB, Kisilevsky R . Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A . J. Biol. Chem. . 272 . 1 . 406–13 . 1997 . 8995276 . 10.1074/jbc.272.1.406 . free .
• Hershkoviz R . Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion . Am. J. Physiol. . 273 . 1 Pt 1 . C179–87 . 1997 . 9252455 . 10.1152/ajpcell.1997.273.1.C179. Preciado-Patt L . Lider O . Fridkin . M . Dastych . J . Metcalfe . DD . Mekori . YA .
• Migita K . Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts . Lab. Invest. . 78 . 5 . 535–9 . 1998 . 9605178 . Kawabe Y . Tominaga M . Origuchi . T . Aoyagi . T . Eguchi . K .
• Urieli-Shoval S, Cohen P, Eisenberg S, Matzner Y . Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium . J. Histochem. Cytochem. . 46 . 12 . 1377–84 . 1999 . 9815279 . 10.1177/002215549804601206. free .

Notes and References

1. Steel DM, Sellar GC, Uhlar CM, Simon S, DeBeer FC, Whitehead AS . A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2) . Genomics . 16 . 2 . 447–54 . Jul 1993 . 7686132 . 10.1006/geno.1993.1209 .
2. Web site: Entrez Gene: SAA2 Serum amyloid A2.