| Jurisdiction: | Diocese |
| San Carlos de Venezuela | |
| Latin: | Dioecesis Sancti Caroli in Venetiola |
| Country: | Venezuela |
| Rite: | Latin Rite |
| Established: | 16 May 1972 (years ago) |
| Cathedral: | Catedral de la Inmaculada Concepción |
| Area Km2: | 14,800 |
| Population: | 268,654 |
| Population As Of: | 2004 |
| Catholics: | 258,090 |
| Catholics Percent: | 96.1 |
| Bishop: | Polito Rodríguez Méndez |
| Emeritus Bishops: | Jesús Tomás Zárraga Colmenares |
| Map: | Diócesis de San Carlos de Venezuela.svg |
The Roman Catholic Diocese of San Carlos de Venezuela (la|Dioecesis Sancti Caroli in Venetiola ) is a diocese located in the city of San Carlos in the ecclesiastical province of Valencia en Venezuela in Venezuela.
On 16 May 1972 Pope Paul VI established the Diocese of San Carlos de Venezuela from Diocese of Valencia.