RHOB explained

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.^{[1] [2]}

RHOB is a member of the Rho GTP-binding protein family.^[3]

Interactions

RHOB has been shown to interact with CIT,^[4] ARHGEF3,^[5] ARHGDIG^[6] and RHPN2.^[7]

See also

• neural crest

Further reading

• Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE . January 2011 . RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice . The American Journal of Pathology . 178 . 1 . 245–52 . 10.1016/j.ajpath.2010.11.040 . 3069827 . 21224061.
• Casey PJ, Seabra MC . March 1996 . Protein prenyltransferases . The Journal of Biological Chemistry . 271 . 10 . 5289–92 . 10.1074/jbc.271.10.5289 . 8621375 . free.
• Adamson P, Marshall CJ, Hall A, Tilbrook PA . October 1992 . Post-translational modifications of p21rho proteins . The Journal of Biological Chemistry . 267 . 28 . 20033–8 . 10.1016/S0021-9258(19)88661-1 . 1400319 . free.
• Cannizzaro LA, Madaule P, Hecht F, Axel R, Croce CM, Huebner K . February 1990 . Chromosome localization of human ARH genes, a ras-related gene family . Genomics . 6 . 2 . 197–203 . 10.1016/0888-7543(90)90557-B . 2407642.
• Chardin P, Madaule P, Tavitian A . March 1988 . Coding sequence of human rho cDNAs clone 6 and clone 9 . Nucleic Acids Research . 16 . 6 . 2717 . 10.1093/nar/16.6.2717 . 336400 . 3283705.
• Madaule P, Axel R . May 1985 . A novel ras-related gene family . Cell . 41 . 1 . 31–40 . 10.1016/0092-8674(85)90058-3 . 3888408 . 32708060.
• Robertson D, Paterson HF, Adamson P, Hall A, Monaghan P . May 1995 . Ultrastructural localization of ras-related proteins using epitope-tagged plasmids . The Journal of Histochemistry and Cytochemistry . 43 . 5 . 471–80 . 10.1177/43.5.7537292 . 7537292 . free.
• Armstrong SA, Hannah VC, Goldstein JL, Brown MS . April 1995 . CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB . The Journal of Biological Chemistry . 270 . 14 . 7864–8 . 10.1074/jbc.270.14.7864 . 7713879 . free.
• Bonaldo MF, Lennon G, Soares MB . September 1996 . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . 10.1101/gr.6.9.791 . 8889548 . free.
• Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B . November 1996 . RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG . The Journal of Biological Chemistry . 271 . 48 . 30366–74 . 10.1074/jbc.271.48.30366 . 8939998 . free.
• Mellor H, Flynn P, Nobes CD, Hall A, Parker PJ . February 1998 . PRK1 is targeted to endosomes by the small GTPase, RhoB . The Journal of Biological Chemistry . 273 . 9 . 4811–4 . 10.1074/jbc.273.9.4811 . 9478917 . free.
• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . June 1998 . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 3 . 169–76 . 10.1093/dnares/5.3.169 . 9734811 . free.
• Liu JP, Jessell TM . December 1998 . A role for rhoB in the delamination of neural crest cells from the dorsal neural tube . Development . 125 . 24 . 5055–67 . 10.1242/dev.125.24.5055 . 9811589.
• Gampel A, Parker PJ, Mellor H . September 1999 . Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB . Current Biology . 9 . 17 . 955–8 . 1999CBio....9..955G . 10.1016/S0960-9822(99)80422-9 . 10508588 . 9616910 . free.
• Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W . January 2000 . The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly . Cell Death and Differentiation . 7 . 1 . 25–36 . 10.1038/sj.cdd.4400616 . 10713718 . free.
• ((Liu Ax)), Du W, Liu JP, Jessell TM, Prendergast GC . August 2000 . RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors . Molecular and Cellular Biology . 20 . 16 . 6105–13 . 10.1128/MCB.20.16.6105-6113.2000 . 86086 . 10913192.
• Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR . January 2001 . Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding . The Journal of Cell Biology . 152 . 1 . 111–26 . 10.1083/jcb.152.1.111 . 2193662 . 11149925.
• Cerniglia GJ, Bernhard EJ, Prendergast GC . May 2001 . RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage . Proceedings of the National Academy of Sciences of the United States of America . 98 . 11 . 6192–7 . 2001PNAS...98.6192L . 10.1073/pnas.111137198 . 33444 . 11353846 . free.
• Diviani D, Soderling J, Scott JD . November 2001 . AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation . The Journal of Biological Chemistry . 276 . 47 . 44247–57 . 10.1074/jbc.M106629200 . 11546812 . free.
• Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Muñoz-Antonia T . March 2002 . RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1 . The Journal of Biological Chemistry . 277 . 10 . 8500–7 . 10.1074/jbc.M104367200 . 11741970 . free.

Notes and References

1. Web site: Entrez Gene: RHOB ras homolog gene family, member B .
2. Chardin P, Madaule P, Tavitian A . March 1988 . Coding sequence of human rho cDNAs clone 6 and clone 9 . Nucleic Acids Research . 16 . 6 . 2717 . 10.1093/nar/16.6.2717 . 336400 . 3283705.
3. Wennerberg K, Der CJ . March 2004 . Rho-family GTPases: it's not only Rac and Rho (and I like it) . Journal of Cell Science . 117 . Pt 8 . 1301–12 . 10.1242/jcs.01118 . 15020670 . free.
4. Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S . December 1995 . A novel partner for the GTP-bound forms of rho and rac . FEBS Letters . 377 . 2 . 243–8 . 10.1016/0014-5793(95)01351-2 . 8543060 . free.
5. Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K . November 2002 . XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC . The Journal of Biological Chemistry . 277 . 45 . 42964–72 . 10.1074/jbc.M207401200 . 12221096 . free.
6. Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B . November 1996 . RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG . The Journal of Biological Chemistry . 271 . 48 . 30366–74 . 10.1074/jbc.271.48.30366 . 8939998 . free.
7. Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I . December 2002 . Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP . European Journal of Biochemistry . 269 . 24 . 6241–9 . 10.1046/j.1432-1033.2002.03343.x . 12473120 . 23901713.