| Renato De Manzano | |
| Birth Date: | 19 March 1907 |
| Birth Place: | Trieste, Austria-Hungary, now Italy |
| Death Place: | Trieste, Italy |
| Position: | Midfielder |
| Years1: | 1925–1927 |
| Years2: | 1927–1928 |
| Years3: | 1928–1929 |
| Years4: | 1929–1933 |
| Years5: | 1933–1934 |
| Years6: | 1934–1936 |
| Years7: | 1936–1937 |
| Years8: | 1937–1939 |
| Years9: | 1939–1940 |
| Clubs4: | Triestina |
| Clubs9: | Cremonese |
| Caps3: | 27 |
| Caps4: | 131 |
| Caps5: | 14 |
| Caps6: | 55 |
| Caps7: | 11 |
| Caps8: | 57 |
| Caps9: | 9 |
| Goals3: | 22 |
| Goals4: | 32 |
| Goals5: | 2 |
| Goals6: | 6 |
| Goals7: | 0 |
| Goals8: | 13 |
| Goals9: | 4 |
Renato De Manzano (March 19, 1907 in Trieste, Austria-Hungary, now Italy - September 25, 1968 in Trieste) was an Italian professional football player.