RAB9A explained

Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene.^{[1] [2]}

Interactions

RAB9A has been shown to interact with RABEPK,^[3] TIP47^[4] and the Biogenesis of lysosome-related organelles complex 3.^[5]

Further reading

• Shapiro AD, Pfeffer SR . Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides . J. Biol. Chem. . 270 . 19 . 11085–90 . 1995 . 7744738 . 10.1074/jbc.270.19.11085 . free.
• Soldati T, Riederer MA, Pfeffer SR . Rab GDI: a solubilizing and recycling factor for rab9 protein . Mol. Biol. Cell . 4 . 4 . 425–34 . 1993 . 8389620 . 300943 . 10.1091/mbc.4.4.425 .
• Díaz E, Schimmöller F, Pfeffer SR . A novel Rab9 effector required for endosome-to-TGN transport . J. Cell Biol. . 138 . 2 . 283–90 . 1997 . 9230071 . 2138197 . 10.1083/jcb.138.2.283 .
• de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J . Small GTP-binding proteins in human endothelial cells . Br. J. Haematol. . 103 . 1 . 15–9 . 1998 . 9792283 . 10.1046/j.1365-2141.1998.00965.x . 24857520 . free .
• Shisheva A, Chinni SR, DeMarco C . General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications . Biochemistry . 38 . 36 . 11711–21 . 1999 . 10512627 . 10.1021/bi990200r .
• Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR . Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 . Science . 292 . 5520 . 1373–6 . 2001 . 11359012 . 10.1126/science.1056791 . 2001Sci...292.1373C . 31343936 .
• Orzaez D, de Jong AJ, Woltering EJ . A tomato homologue of the human protein PIRIN is induced during programmed cell death . Plant Mol. Biol. . 46 . 4 . 459–68 . 2001 . 11485202 . 10.1023/A:1010618515051 . 8587440 .
• Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U, Müller CW . Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family . EMBO J. . 20 . 22 . 6180–90 . 2002 . 11707390 . 125740 . 10.1093/emboj/20.22.6180 .
• Barbero P, Bittova L, Pfeffer SR . Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells . J. Cell Biol. . 156 . 3 . 511–8 . 2002 . 11827983 . 2173336 . 10.1083/jcb.200109030 .
• Hanna J, Carroll K, Pfeffer SR . Identification of residues in TIP47 essential for Rab9 binding . Proc. Natl. Acad. Sci. U.S.A. . 99 . 11 . 7450–4 . 2002 . 12032303 . 124251 . 10.1073/pnas.112198799 . 2002PNAS...99.7450H . free .
• Walter M, Davies JP, Ioannou YA . Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes . J. Lipid Res. . 44 . 2 . 243–53 . 2004 . 12576506 . 10.1194/jlr.M200230-JLR200 . free .
• Seaman MN . Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer . J. Cell Biol. . 165 . 1 . 111–22 . 2004 . 15078902 . 2172078 . 10.1083/jcb.200312034 .
• Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ . High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target . J. Biol. Chem. . 279 . 38 . 40204–8 . 2004 . 15263003 . 10.1074/jbc.M407114200 . free.
• Ganley IG, Carroll K, Bittova L, Pfeffer S . Rab9 GTPase regulates late endosome size and requires effector interaction for its stability . Mol. Biol. Cell . 15 . 12 . 5420–30 . 2005 . 15456905 . 532021 . 10.1091/mbc.E04-08-0747 .
• Ganley IG, Pfeffer SR . Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells . J. Biol. Chem. . 281 . 26 . 17890–9 . 2006 . 16644737 . 3650718 . 10.1074/jbc.M601679200 . free .
• Aivazian D, Serrano RL, Pfeffer S . TIP47 is a key effector for Rab9 localization . J. Cell Biol. . 173 . 6 . 917–26 . 2006 . 16769818 . 2063917 . 10.1083/jcb.200510010 .

Notes and References

1. Davies JP, Cotter PD, Ioannou YA . Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene . Genomics . 41 . 1 . 131–4 . May 1997 . 9126495 . 10.1006/geno.1997.4644 .
2. Web site: Entrez Gene: RAB9A RAB9A, member RAS oncogene family.
3. Díaz E, Schimmöller F, Pfeffer SR . A novel Rab9 effector required for endosome-to-TGN transport . J. Cell Biol. . 138 . 2 . 283–90 . July 1997 . 9230071 . 2138197 . 10.1083/jcb.138.2.283 .
4. Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR . Role of Rab9 GTPase in facilitating receptor recruitment by TIP47 . Science . 292 . 5520 . 1373–6 . May 2001 . 11359012 . 10.1126/science.1056791 . 2001Sci...292.1373C . 31343936 .
5. Kloer DP, Rojas R, Ivan V, Moriyama K, van Vlijmen T, Murthy N, Ghirlando R, van der Sluijs P, Hurley JH, Bonifacino JS . Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9 . J. Biol. Chem. . 285 . 10 . 7794–7804 . March 2010 . 20048159 . 2844223 . 10.1074/jbc.M109.069088 . free .